About My Health Careers Internship MedBlogs Contact us

Rapid and Efficient Way of Transforming Yeast for Industrial Biotechnology

by Anjali Aryamvally on May 29, 2018 at 8:12 PM
Font : A-A+

Rapid and Efficient Way of Transforming Yeast for Industrial Biotechnology

New study has created a new way of speeding up the genome evolution of baker's yeast to develop a synthetic yeast strain that can be transformed on demand for use in various industrial applications. Baker's yeast also called Saccharomyces cerevisiae is the same yeast people use for bread and beer production.

A research team led by Prof. DAI Junbiao at the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences, in collaboration with Prof. Patrick Cai from the Manchester Institute of Biotechnology, developed a "rapid, efficient and universal" way of transforming yeast at the molecular level using a method called SCRaMbLE (Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution).


This system allows researchers to "reshuffle the deck of cards" for the genome, and customize new yeast strains that can recombine on demand with each other to generate novel genome combinations not found in nature before.

Yeast is a very well understood organism and in a biological sense humans and yeast share a number of similarities in their genetic makeup. Therefore, re-building the yeast genome from the ground up helps us better understand the basis of human life.

"Essentially, we can fast-track the engineering cycle. Usually it would take years to optimize yeast strains for industrial applications, but with SCRaMbLE it could take just two or three days. When you can couple engineering with evolution, you have a very powerful tool in hand," said Prof. Cai.

The SCRaMBLE system not only allows researchers to integrate pathways into the synthetic yeast genome, but the yeast itself can also be evolved to become a better host under stress conditions, providing a unique opportunity for it to evolve, adapt to challenges and perform in extreme conditions, such as extreme temperatures and toxic environments.

This makes it particularly attractive for industrial biotechnology applications, such as the production of advanced medicines. This could have massive implications for the future study of DNA and the mass production of new medicines to treat illnesses such as malaria and tuberculosis (TB).

"One of the most exciting developments in industrial biotechnology is the synergy between synthetic biology and metabolic engineering that is enabling us to produce fuels, novel medicines and high value chemicals, nutrition supplements, anti-tumor molecules and antibiotics," said Prof. Cai. "I hope that the technology we have developed here will go some way to speeding up the process for the bio-manufacture of these important products."

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Candida Diet Histoplasmosis 

Recommended Reading
Yeast-based Protein Therapies can Treat Cancer
The complex metabolism of yeast cells has been brought into light after years. Yeast produces more ....
Baker's Yeast Plays A New Role In Drug Discovery
Yeast cells are a simpler version of human cells. The major challenge is to understood it at the ......
New Blood Test Reduces Diagnosis Time for Candidemia, a Deadly Yeast Infection
A novel blood test developed by UPMC research team was found to perform better than traditional ......
Cough Medicine can be Developed from Bioengineered Yeast
A novel technology has been identified that can change the way essential medicines can be ......
Candida Diet
It is possible to reverse Candida infection through a strictly followed Candida diet plan. Candida d...
Histoplasmosis is a fungal infection caused by breathing spores of the fungus from bird or bat dropp...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use