Unusual alkaloid compound with antiausterity potential from vines found in the Congolese rainforest makes pancreatic cancer cells susceptible to nutrient starvation.
Pancreatic Cancer - All About the Disease, its Diagnosis and Management
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
‘The new compound killed pancreatic cancer cells under conditions of nutrient starvation but not when nutrients were plentiful.’
Pancreatic cancer is one of the deadliest forms of cancer, with a 5-year survival rate of less than 5 percent. Because these cancer cells proliferate so aggressively, they deplete nutrients and oxygen in the region of the tumor. Whereas most cells would die under these extreme conditions, pancreatic cancer cells survive by activating a cell signaling pathway called Akt/mTOR. Some researchers are testing plants for antiausterity compounds that disrupt this pathway. Suresh Awale, Gerhard Bringmann and colleagues previously identified some unusual alkaloid compounds with antiausterity potential from vines found in the Congolese rainforest. Now they wanted to look for additional new compounds from twigs of the vine Ancistrocladus likoko.
The team extracted compounds from ground twigs and separated them by high-performance liquid chromatography. They then characterized the 3D structure of a new alkaloid compound, which they named ancistrolikokine E3.
Quiz on Pancreatic Cancer
Pancreatic cancer is often diagnosed at a late stage and can be fatal. Test your knowledge on pancreatic cancer by taking this quiz.
Pancreatic cancer is often diagnosed at a late stage and can be fatal. Test your knowledge on pancreatic cancer by taking this quiz.
Source-Eurekalert
Adolescent Obesity May Increase the Risk of Pancreatic Cancer in Adulthood
Adolescent obesity is associated with increased risk of pancreatic cancer later in life, finds a new study.
Adolescent obesity is associated with increased risk of pancreatic cancer later in life, finds a new study.
Manohar Parrikar Has Pancreatic Cancer Admits the Goa State Administration
Goa Government Finally Admits that CM Parrikar Has Pancreatic Cancer, the admission has come after a series of relentless demands made by opposition parties to know whether the chief minister was well enough to do his duties.
Goa Government Finally Admits that CM Parrikar Has Pancreatic Cancer, the admission has come after a series of relentless demands made by opposition parties to know whether the chief minister was well enough to do his duties.
