Provoking Obsessive Thoughts Leads to Brain Changes in Man With Obsessive-compulsive Disorder

by Colleen Fleiss on  May 29, 2019 at 8:20 AM Mental Health News
RSS Email Print This Page Comment bookmark
Font : A-A+

In obsessive-compulsive disorder (OCD), thoughts that lead to compulsive behavior correspond with physiological changes in the brain, according to a new case study. The article is published ahead of print in the Journal of Neurophysiology (JNP).
Provoking Obsessive Thoughts Leads to Brain Changes in Man With Obsessive-compulsive Disorder
Provoking Obsessive Thoughts Leads to Brain Changes in Man With Obsessive-compulsive Disorder

Without treatment, OCD compulsions can often interrupt a person's daily routine and may interfere with personal and professional relationships. Medications and cognitive behavioral therapy are standard treatments for OCD but in some cases are not enough to manage symptoms. Deep brain stimulation—which delivers electrical impulses to targeted areas of the brain to change its activity—has become a therapeutic option for hard-to-treat OCD.

Show Full Article

For this case study, researchers observed a 64-year-old man with OCD whose compulsions involved personal hygiene. His symptoms were not responsive to medication. Researchers explored how the brain physiologically reacts to OCD compulsions by performing deep brain stimulation and provoking compulsive behavior while the man was awake during surgery. The research team recorded from and stimulated a region of the brain called the nucleus accumbens—a collection of nerve cells (neurons) that play an important role in the brain's reward circuitry.

The researchers designed a provocation test based on the man's self-reported obsession with cleanliness. They placed a microelectrode in two different sites close to the nucleus accumbens. The researchers gave the man a toothbrush and asked him to "imagine brushing your teeth with this dirty toothbrush." One site showed an increase in neuronal activity during the provocation while the other site showed a relative decrease. This could be due to the different types of neurons in the two sites and their different reactions to the verbal trigger. However, the broader "finding that provocation of the patient's contamination obsession induced physiological changes in [the nucleus accumbens] is an initial step forward to better understand how obsessions are processed in the human brain," the researchers wrote.

Read the full article, "Case studies in neuroscience: The electrophysiology of a human obsession in nucleus accumbens," published ahead of print in JNP.

Source: Newswise

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

Recommended Reading

More News on:

Parkinsons Disease Parkinsons Disease Surgical Treatment Brain Brain Facts Ataxia Language Areas in The Brain Loss of Taste Ways to Improve your Intelligence Quotient (IQ) 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive