Imagine a situation where you are fighting hard for your life but your opponent doesn't just go down.
The same can be said of highly treatment-resistant cancers, such as head and neck cancer, where during radiation and chemotherapy some cancer cells repair themselves, survive and thrive. Head and neck cancer is the sixth most common cancer in the world, but the late detection and treatment resistance result in a high mortality rate.
Researchers Discover a New Function of Body's Tumor-Suppressing Protein
At Cold Spring Harbor Laboratory (CSHL), researchers have discovered a new function of the body's most important tumor-suppressing protein.
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Now, University of Michigan researchers have found that a particular protein—TRIP13—encourages those cancer cells to repair themselves. And they have identified an existing chemical that blocks this mechanism for cell repair.
"This is a very significant advance, because identifying the function of the protein that fuels the repair of cancer cells and having an existing chemical that blocks the process, could speed the process of moving to clinical trials," said principal investigator Nisha D'Silva, U-M professor of dentistry and associate professor of pathology.
![Researchers Sequence the Entire Genome of African Rice to Beat Global Hunger]( "Researchers Sequence the Entire Genome of African Rice to Beat Global Hunger")
The entire genome of the African rice has been sequenced by researchers in an attempt to solve global hunger challenges
Typically, if scientists discover a promising drug therapy target, it takes years to develop drug compounds from scratch and move these into clinical trials.
If cell DNA is damaged and the cell cannot repair the damage, the cell dies. In head and neck cancers, D'Silva and colleagues showed that cancer cells that overexpress TRIP13 were able to repair their DNA enough to survive and continue to grow as cancer.
"Targeting this repair mechanism with specific drugs could increase effectiveness of treatment and improve survival of cancer patients," D'Silva said. "And given the overexpression of TRIP13 in several treatment-resistant cancers, this strategy will likely be important for multiple cancers."
Source: Eurekalert
Researchers Sequence the Entire Genome of African Rice to Beat Global Hunger
The entire genome of the African rice has been sequenced by researchers in an attempt to solve global hunger challenges
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Typically, if scientists discover a promising drug therapy target, it takes years to develop drug compounds from scratch and move these into clinical trials.
If cell DNA is damaged and the cell cannot repair the damage, the cell dies. In head and neck cancers, D'Silva and colleagues showed that cancer cells that overexpress TRIP13 were able to repair their DNA enough to survive and continue to grow as cancer.
"Targeting this repair mechanism with specific drugs could increase effectiveness of treatment and improve survival of cancer patients," D'Silva said. "And given the overexpression of TRIP13 in several treatment-resistant cancers, this strategy will likely be important for multiple cancers."
Source: Eurekalert
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