About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Protein 'TDP-43' Found in Two-Thirds of Those With Alzheimer’s Dementia

by Dr. Trupti Shirole on October 2, 2016 at 11:00 PM
Font : A-A+

 Protein 'TDP-43' Found in Two-Thirds of Those With Alzheimer’s Dementia

The hallmark pathologies of Alzheimer's disease are the accumulation of the protein beta-amyloid (called plaques) and an abnormal form of the protein tau (called tangles). However, research from the Rush Alzheimer's Disease Center and other groups has shown that the majority of persons with clinical Alzheimer's dementia also develop other disease pathologies in their brains as well, such as small strokes or protein deposits called Lewy bodies.

This combination, called 'mixed pathologies,' increases the risk for developing diagnosed Alzheimer's dementia above and beyond just having plaques and tangles in the brain.

Advertisement


A recently-recognized pathologic protein in the brain may play a larger role in the development of clinical Alzheimer's disease dementia than previously recognized, revealed a study by researchers at Rush University Medical Center. The findings of the study of nearly 1,000 older adults were published in the journal, Brain.

"This finding could help researchers to understand the cause of memory loss and lead to new ways to approach studying Alzheimer's disease," said Bryan James, study author and epidemiologist with the Rush Alzheimer's Disease Center. "Our study found that when the main characteristic pathologies of Alzheimer's disease, plaques and tangles, were mixed with a pathologic protein called TDP-43 in the brain, the combination was more likely to result in diagnosed Alzheimer's dementia than plaques and tangles alone."
Advertisement

The abnormal protein, TDP-43 (short for 'hyperphosphorylated transactive response DNA-binding protein 43'), previously has been associated with frontal temporal dementia and amyotrophic lateral sclerosis (ALS, sometimes called Lou Gehrig's disease). In recent years, TDP-43 also has been found in the brains of persons with other diseases, but most recently in Alzheimer's disease.

"The clinical disease that we call 'Alzheimer's disease' is looking more and more like the result of the accumulation of a number of disease processes in the brain of older persons," James said. The majority of persons with diagnosed Alzheimer's dementia actually have mixed pathologies in their brains — not just the plaques and tangles that are the known hallmarks of Alzheimer's disease.

"In particular, mixed Alzheimer's and TDP-43 pathologies appear to be an under-recognized yet common form of mixed pathologies that contributes to the development of clinical Alzheimer's dementia," James said. "This is one of the first studies to examine TDP-43 and Alzheimer's disease in the context of mixed pathologies."

The Brain paper built on previous research by examining whether TDP-43 was associated with an increased likelihood of a diagnosis of Alzheimer's dementia in persons both with and without pathologic Alzheimer's disease.

The new study examined brain pathology, drawing on tissue samples from 946 deceased older men and women who had been enrolled in one of two cohort studies by the Rush Alzheimer's Disease Center, the Rush Memory and Aging Project or the Religious Orders Study. Participants in both studies agree to donate their brains to research after their death.

TDP-43 was present in the brains of about half of the participants and in two-thirds of the brains of persons who had been diagnosed with Alzheimer's dementia while alive. More than a third of the participants had mixed Alzheimer's (plaques and tangles) and TDP-43 pathologies in their brain. Mixed Alzheimer's and TDP-43 pathologies were associated with a higher likelihood of diagnosed Alzheimer's dementia at death than plaques and tangles alone.

"These data are exciting, because an improved understanding of the TDP-43 protein has potential to guide alternative treatment strategies for Alzheimer's disease," James said.

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Get Involved and Stand Up for Human Rights on Human Rights Day 2022
Coronary Artery Bypass Grafting
Macronutrients Calculator for Weight Loss
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Magical Millets for Your Health Diet and Nutrition Tips for Athletes Nutrition IQ Dementia Vascular Dementia 

Most Popular on Medindia

Color Blindness Calculator Calculate Ideal Weight for Infants Nutam (400mg) (Piracetam) Pregnancy Confirmation Calculator Hearing Loss Calculator Sanatogen Loram (2 mg) (Lorazepam) Indian Medical Journals A-Z Drug Brands in India Blood Donation - Recipients
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Protein 'TDP-43' Found in Two-Thirds of Those With Alzheimer’s Dementia Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests