Protein Synthesis Regulatory Factor Caprin1 Essential for Long-term Memory

by Anjali Aryamvally on  November 26, 2017 at 10:41 AM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

The function of RNG105 (aka Caprin1) is essential for the formation of long-term memory, suggests a research team led by Associate Professor Nobuyuki Shiina of the National Institute for Basic Biology.
Protein Synthesis Regulatory Factor Caprin1 Essential for Long-term Memory
Protein Synthesis Regulatory Factor Caprin1 Essential for Long-term Memory

RNG105 is a factor involved in protein synthesis in the vicinity of synapses, which transmit information between neurons. Mice who have lost RNG105 in the cerebrum and hippocampus can form short-term memories of several minutes, but the research group has shown that long-term memory, developed over several days to one week, does not form in these mice. Also, when long-term memory is formed, it is important that the synaptic structure between neurons enlarges and new neural circuitry for memory is retained (called synaptic potentiation), in mice lacking RNG105 however the group found that synaptic potentiation is not sustained. They also found that RNG105-regulated protein synthesis is involved in the correct placement of AMPA receptors in synapses, which are known to be important for memory retention.

Show Full Article


Dr. Shiina has said, "This new finding has advanced our understanding of long-term memory and paved the way for applied research towards improving long-term memory in human diseases." The results of this research were published in 'eLife' .



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Recommended Reading

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive