Researchers from Rhode Island Hospital have identified a protein that could play a crucial role in surviving liver sepsis. Sepsis is a serious condition in which the body is fighting a severe infection that has traveled through the bloodstream and is associated with a high mortality rate. Very few advances have been made to date on the biological mechanisms that cause septic morbidity and mortality. One focus, however, is Receptor Interacting Protein 1 (RIP1). This adaptor protein has been shown to have a signaling function for cells when it reacts with other receptors, and serves to switch an apoptotic cell death (a highly regulated form of death/cell suicide) to a necrotic death (a more disorderly death). But RIP1 acts both as a ¡°death switch¡± and as a pro-survival mechanism. The ability to identify the triggers for these functions may play a key role in treating sepsis in the future. The study is published online in advance of print in the journal Shock. Alfred Ayala, Ph.D., a senior researcher in the division of surgical research within the department of surgery at Rhode Island Hospital and a professor at The Warren Alpert Medical School of Brown University, is the senior author of the study. Ayala says, ¡°We initially hypothesized that RIP1 was involved in the alteration of the apoptotic death pathway to result in a kind of ¡®programmed necrosis¡¯ in the liver. What we actually found was an alternative role for RIP1 in the pathobiology of sepsis in the liver ¡ª one that also promotes cellular survival.¡± Sam McNeal, the lead author on the study and a graduate student at the Alpert Medical School and Rhode Island Hospital, says, ¡°In our animal models, we discovered that survival decreased when we suppressed RIP1. Our findings imply that RIP1¡äs capacity to contribute to the onset of programmed cell death is not its central role in the septic animal and it appears to be necessary for survival of septic injury.¡± RIP1 is a multifunctional adaptor protein that has three domains: kinase, intermediate and death. The findings from this study indicate that the kinase domain of this protein is more involved in cell function than was previously thought. McNeal explains that this finding is important because knowledge of how the kinase domain is regulated may uncover new therapeutic targets that can be used to mitigate the effects of cellular/organ damage caused by trauma, shock, sepsis or other related conditions. McNeal says, ¡°The function of RIP1 is much more nuanced than we originally thought. We believe it plays a key role in cell function during sepsis, and if the pro-survival trigger can be identified, it could have major implications on how sepsis is treated in the future.¡± Source: Medindia << Ritalin Improves Brain Function In Iron Deficient Rats Sportspersons At Risk From Alcohol Industry Sponsorship >> Recommended Reading Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Diet and Nutrition Tips for Athletes Athletes can be physically fit by consuming a well balanced nutritious diet, which keeps them mentally alert not only during and after the sports events but all around the year. Here are some simple and essential diet and nutrition tips for athletes. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Septicemia Septicemia or sepsis is a serious illness wherein a patient develops symptoms due to presence of microbes or their toxins in the blood. Septicemia or sepsis is caused by bacteria, viruses and fungi. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Noscaphene (Noscapine) Iron Intake Calculator The Essence of Yoga More News on: Hepatitis ALiverWilson's DiseaseSepticemiaDiet and Nutrition Tips for AthletesMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?