Protein Inhibitor Drug Benefits AML Patients

In a study of patients with acute myeloid leukemia (AML) with relapsed or refractory disease, ivosidenib, an experimental drug known to inhibit a protein often mutated in several cancers was found to be safe, resulting in durable remissions.

The multi-center Phase I trial, led by researchers at The University of Texas MD Anderson Cancer Center, was designed to determine ivosidenib's safety and efficacy in treatment of patients with a form of AML in which the enzyme isocitrate dehydrogenase 1 (IDH1) is mutated. IDH1 mutations occur in 6 to 10 percent of AML patients. Findings are published today in the June 2 online issue of the New England Journal of Medicineand presented at the American Society of Clinical Oncology Annual Meeting in Chicago.

‘Ivosidenib, a protein inhibitor drug was found to be safe and effective with durable remissions in patients with IDH1-mutant acute myeloid leuekemia (AML).’

This first study of ivosidenib in humans, which enrolled patients between March 2014 and May 2017, administered a daily dose of the targeted IDH1 inhibitor to 258 patients.

"Ivosidenib, when administered orally as a single agent, was associated with acceptable side effects and induced durable and deep remissions," said Courtney DiNardo, M.D., assistant professor of Leukemia at MD Anderson. "In the trial's primary analysis cohort of 125 patients with IDH1-mutated relapsed or refractory AML treated at the recommended 500 mg daily dose, ivosidenib led to an overall response rate of 41.6 percent and a complete remission rate of 21.6 percent."

The study also reported that 30.4 percent of those 125 patients were in complete remission but with blood counts not fully restored. The overall survival rate was 50.1 percent at 18 months, as compared to historical overall survival of less than five months for patients with relapsed AML and two prior therapies.

"Among patients achieving complete remission or complete remission with partial hematologic recovery, 21 percent had no residual detectable IDH1 mutations," said DiNardo. "While the significance and prognostic impact of ongoing detection of IDH1 mutations remains unknown, further evaluation of changes in IDH1 mutations over time with ivosidenib therapy will be important avenues of research."

Source: Eurekalert

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