About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Protein Atf4 Found to Regulate Bone-cell Control of Energy Generation

by Rajashri on August 12, 2009 at 9:57 PM
Font : A-A+

 Protein Atf4 Found to Regulate Bone-cell Control of Energy Generation

It has come to light very recently that bone cells known as osteoblasts have a role in controlling the biochemical reactions that generate energy via secretion of the molecule osteocalcin.

Gerard Karsenty and colleagues, at Columbia University College of Physicians and Surgeons, New York, therefore hypothesized that osteoblasts express a regulatory gene(s) that controls this osteoblast function and then identified Atf4 as this regulatory gene in mice.

Advertisement

Atf4 is a protein expressed predominantly in osteoblasts that is known to regulate many osteoblast functions. The researchers therefore analyzed mice lacking Atf4 and found that they have lower fat mass and blood glucose (a major source of energy) levels than control mice. The lower blood glucose levels were due to increased expression and secretion of the hormone insulin, which promotes liver, fat, and muscle cells to take up glucose. Sensitivity to insulin in the liver, fat, and muscle was also enhanced. Several genetic experiments established that lack of Atf4 in osteoblasts was central to these abnormal characteristics of mice lacking Atf4 and further analysis indicated the underlying mechanism. Specifically, Atf4 directly increased expression of the Esp gene, which makes a protein that decreases the activity of osteocalcin. As Atf4 in osteoblasts was already known to regulate bone formation and mineralization, the authors conclude that Atf4 regulates many, but not all, osteoblast functions.



Source: Eurekalert
RAS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Is COVID-19 Vaccination during Pregnancy Safe?
Sensory Processing Disorder (SPD)
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diet and Nutrition Tips for Athletes 

Recommended Reading
Advantages of Bone Marrow Stem Cells
Encyclopedia section of medindia explains in brief about the advantages of using bone marrow cells...
Pagets And Jaw Bone Diseases
Osteitis deformans, or Pagets disease of the bone, is the deformity of the bone. Symptoms include .....
Diet and Nutrition Tips for Athletes
Athletes can be physically fit by consuming a well balanced nutritious diet, which keeps them mental...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use