About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Protective Effect of α-Synuclein Reduces the Depression Manifestations of PD

by Bidita Debnath on July 19, 2014 at 11:50 PM
Font : A-A+

 Protective Effect of α-Synuclein Reduces the Depression Manifestations of PD

In a methamphetamine-induced model of Parkinson's disease (PD), the over-expression of α-synuclein is a major factor in the death of dopaminergic neurons.

Dr. Huijun Wang, School of Basic Medical Sciences, Southern Medical University, China and his team injected α-synuclein-shRNA lentivirus stereotaxically into the right striatum of experimental rats to inhibit α-synuclein mRNA and protein expression.

Advertisement

Results showed that after α-synuclein knockdown, the depression manifestations of PD rats were reduced, striatal dopamine and tyrosine hydroxylase levels as well as superoxide dismutase activity were significantly increased, but the levels of reactive oxygen species, malondialdehyde, nitric oxide synthase and nitrogen monoxide were decreased, and simultaneously, the number of apoptotic cells in the striatum was significantly decreased.

The authors considered α-synuclein has the capacity to reverse methamphetamine-induced apoptosis of dopaminergic neurons in the rat striatum by inhibiting oxidative stress and improving dopaminergic system function. Related results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014).
Advertisement

Article: " Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons," by Yunchun Tai1, Ling Chen1, Enping Huang1, Chao Liu1, 2, Xingyi Yang1, Pingming Qiu1, Huijun Wang1 (1 Department of Forensic Medicine, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, China; 2 Guangzhou Forensic Science Institute, Guangzhou, Guangdong Province, China)Tai YC, Chen L, Huang EP, Liu C, Yang XY, Qiu PM, Wang HJ. Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons. Neural Regen Res. 2014;9(9):951-958.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Adolescence Depression Depression Stress Relief Through Alternative Medicine Andropause / Male Menopause Pregnancy and Complications Bereavement Holistic Management for Depression Tourette Syndrome Dealing with Menopause symptoms through lifestyle changes Tired All The Time 

Most Popular on Medindia

Sinopril (2mg) (Lacidipine) Hearing Loss Calculator The Essence of Yoga How to Reduce School Bag Weight - Simple Tips Sanatogen Daily Calorie Requirements Selfie Addiction Calculator Noscaphene (Noscapine) Drug - Food Interactions Loram (2 mg) (Lorazepam)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Protective Effect of α-Synuclein Reduces the Depression Manifestations of PD Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests