Prosthetic Hands Benefited By Bio-Engineered Nerve-Muscle Connection

University of Michigan scientists have developed modern tissue engineering system that could improve the function of prosthetic hands and possibly restore the sense of touch for injured patients.

The research project started because there was a need for better prosthetic devices for troops wounded in Afghanistan and Iraq.

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"Most of these individuals are typically using a prosthesis design that was developed decades ago. This effort is to make a prosthesis that moves like a normal hand," said Dr. Paul S. Cederna, a plastic and reconstructive surgeon at U-M Health System.

The researchers may help overcome some of the shortcomings of existing robotic prosthetics, which have limited motor control, provide no sensory feedback and can be uncomfortable and cumbersome to wear.

"There is a huge need for a better nerve interface to control the upper extremity prostheses," says Cederna.

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When a hand is amputated, the nerve endings in the arm continue to sprout branches, growing a mass of nerve fibres that send flawed signals back to the brain.

The researchers created what they called an "artificial neuromuscular junction" composed of muscle cells and a nano-sized polymer placed on a biological scaffold.

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Neuromuscular junctions are the body's own nerve-muscle connections that enable the brain to control muscle movement.

The bio-engineered scaffold was placed over the severed nerve endings like a sleeve.

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The muscle cells on the scaffold and in the body bonded and the body's native nerve sprouts fed electrical impulses into the tissue, creating a stable nerve-muscle connection.

In laboratory rats, the bioengineered interface relayed both motor and sensory electrical impulses and created a target for the nerve endings to grow properly.

"The polymer has the ability to pick up signals coming out of the nerve, and the nerve does not grow an abnormal mass of nerve fibers," explained Cederna.

The animal studies indicate the interface may not only improve fine motor control of prostheses, but can also relay sensory perceptions such as touch and temperature back to the brain.

Laboratory rats with the interface responded to tickling of feet with appropriate motor signals to move the limb, said Cederna.

The findings of the study will be presented at the 95th annual Clinical Congress of the American College of Surgeons.

Source-ANI
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