About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Prostate Cancer Spread may be Prevented by Drug for Rare Childhood Cancer

by Kathy Jones on May 1, 2011 at 2:36 PM
Font : A-A+

 Prostate Cancer Spread may be Prevented by Drug for Rare Childhood Cancer

A drug developed to treat Ewing's Sarcoma, a rare childhood cancer, may also help prevent human prostate cancer from spreading, says a new study.

Researchers at Georgetown Lombardi Comprehensive Cancer Center have said that if the drug continues to work well - as they found in their lab- in further laboratory and pre-clinical studies, it may be the first prostate cancer drug specifically designed to stop cancer spread, or metastasis.

Advertisement

"This agent does not kill prostate cancer cells, but limits their ability to spread, which could be hugely beneficial in patients," said the study's lead investigator, Aykut Uren, an associate professor at Georgetown Lombardi.

The agent, YK-4 279, was designed in the GUMC Drug Discovery Program, directed by Milton Brown, a co-author on the paper.

YK-4 279 is also being investigated for the treatment of Ewing's sarcoma and is expected to move quickly into a clinical study.
Advertisement

Recent research has shown that 40 to 70 percent of prostate cancer cells express novel proteins when normal genes such as ETV1 and ERG break off from a chromosome and fuse in to a new location. These new genes produce proteins that push prostate cancer cells to become more aggressive and spread.

Noting that a similar fusion gene produces Ewing's sarcoma, the researchers decided to check if their drug would work in prostate cancer cells.

They applied the agent to prostate cancer cells with chromosomal translocations that expressed either an ERG protein or an ETV1 protein and found that the YK-4 279 did inhibit functions of these proteins, which reduced their motility and invasiveness.

The finding was published online April 29 in PLoS ONE.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Top 9 Reasons Why We Should Practice Kindness
Top 10 Vitamin B12 Foods for Vegetarians - Slideshow
Targeted Screening Program Beneficial for Prostate Cancer Screening
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Prostate Cancer Cancer and Homeopathy Trans-Urethral Resection of the Prostate Acute Lymphoblastic Leukemia Signature Drug Toxicity Prostate Cancer Facts Cancer Facts Cancer Tattoos A Body Art 

Most Popular on Medindia

Loram (2 mg) (Lorazepam) Blood Pressure Calculator The Essence of Yoga Post-Nasal Drip Indian Medical Journals Hearing Loss Calculator Drug Side Effects Calculator Daily Calorie Requirements Drug - Food Interactions Turmeric Powder - Health Benefits, Uses & Side Effects

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use