About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Prostate Cancer: Black Patients Show Stronger Response to Hormone Therapy Than White Patients

by Colleen Fleiss on June 5, 2018 at 2:44 AM
Font : A-A+

Prostate Cancer: Black Patients Show Stronger Response to Hormone Therapy Than White Patients

Anti-hormone therapy abiraterone and the steroid prednisone were found to be more effective for African American men with prostate cancer, according to a study led by Duke Cancer Institute researchers.

While median survival was similar for both black and white participants in the study, the findings suggests that racial determinants may factor into the degree of response in patients. This difference could help drive strategies to improve outcomes in those who respond better to the drugs.

Advertisement


"African-Americans have a 2.5 times greater chance of dying from prostate cancer compared to whites," said Daniel George, M.D., director of Duke's Prostate & Urologic Cancer program, who presented the findings at the 2018 annual meeting of the American Society of Clinical Oncology in Chicago.

"Our study provides prospective evidence that there might be inherited genes that could affect treatment response and track with African ancestry in prostate cancer patients," George said. "We need to look closely at the underlining genetic differences that associate with treatment response and build on that to improve survival for these patients."
Advertisement

George and colleagues enrolled 50 black men and 50 white men in a prospective, multi-center study. All participants had metastatic, recurrent prostate cancer and were treated with the anti-hormone therapy abiraterone and the steroid prednisone.

Responses to therapy, measured by a decline in prostate-specific antigen, or PSA, differed by race. For the African-American men, PSA levels declined at higher rates than they did for white patients and remained stable for a median 16.6 months, compared to 11.5 months for the white participants.

The changes in disease progression were less striking; both groups had a median time to radiographic progression of 16.8 months. Still, the authors said the study suggests a potential strategy for new therapies and hormonal treatment regimens that could narrow the prostate cancer survival disparity between blacks and whites.

"This is the first prospective multicenter study by race of an anti-androgen hormonal therapy in advanced prostate cancer," George said. "Further prospective studies in African-American patients are possible and needed to understand the impact of racial determinants on outcome of new hormonal regimens in earlier disease settings."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Coffee May Help You Fight Endometrial Cancer
Fermented Skin Care
Television Binge-Watching May Boost the Risk of Deadly Blood Clots
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Prostate Cancer Trans-Urethral Resection of the Prostate Reiki and Pranic Healing Prostate Cancer: Treatment Options Prostate Specific Antigen [PSA] Medical Management of Prostate Cancer 

Recommended Reading
Brachytherapy for Prostate Cancer
Learn about two different types of brachytherapy used for treating prostate cancer. Get information ...
Quiz on Prostate Cancer
Prostate cancer is fast gaining as a common cancer form among men; more threatening since its ......
Abiraterone Acetate
Abiraterone acetate is used along with prednisolone (corticosteroid) for treating a type of ......
Prednisone
This medication regulates the symptoms of low corticosteroid levels, and is used to treat ......
Medical Management of Prostate Cancer
Prostate cancer is the second most common cancer in men after skin cancer and it is the sixth leadin...
Prostate Cancer
This cancer affects men over the age of 50 years and screening with rectal examination and PSA can h...
Prostate Cancer: Treatment Options
Treatment options of prostate cancer includes waiting, surgery, radiation, hormone therapy, chemothe...
Prostate Specific Antigen [PSA]
PSA blood test is specific to prostate gland but not necessarily a cancer specific test but is commo...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)