About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Promising Therapy for Children With Crohn's Disease

by Sheela Philomena on August 6, 2012 at 10:17 PM
Font : A-A+

 Promising Therapy for Children With Crohn's Disease

Adalimumab is found to be effective in maintaining remission in certain pediatric patients with Crohn's disease, reveals study.

Steroids are commonly used in Crohn's disease, but can stunt growth and delay puberty. Incidence of this disease, which causes intestinal inflammation, is on the rise in children.

Advertisement

This study is the largest double-blind study of an anti-TNF agent in children with Crohn's disease. It found that more than 80 percent of children with moderate to severe Crohn's disease responded to adalimumab within a month (response was defined as a decrease in Pediatric Crohn's Disease Activity Index ¡Ý 15 points from baseline). By six months, approximately 34 percent of patients were in clinical remission, and after a year, 28.4 percent were in remission.

The promising results of treatment with adalimumab are extremely encouraging, especially in this clinically challenging population resistant to conventional therapy. The goal of treatment is not only to induce and maintain clinical remission, but also to restore and preserve normal growth and pubertal development in these children.
Advertisement

Researchers studied 192 patients, ages 6 to 17 years, across 45 sites in Canada, Europe and the U.S. between April 2007 and May 2010. Depending on their body weight, patients were assigned to either a high-dose group, which received 40 mg of adalimumab every other week or 20 mg of adalimumab every other week. Patients assigned to a low-dose group either received 20 mg of adalimumab every other week or 10 mg of adalimumab every other week, again depending on their body weight. More children that received high than low dose were in remission at week 26, but the difference between dose groups was not statistically significant.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
Fermented Skin Care
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Height and Weight-Kids Reiki and Pranic Healing 

Recommended Reading
Crohns Disease
Crohn's disease or regional enteritis is an inflammatory bowel disease that involves the small ......
Include Bone Age Measurement During Routine Care For Kids With Crohn's Disease
As part of standard practice of care, bone age ought to be measured for pediatric people with ......
MR Enterography Better Than Standard Imaging in Diagnosing Fibrosis Among Pediatric Crohn’s Patients
A new study has found that using MR enterography in detecting active inflammation and diagnosing ......
Early Intro Of Biologic Therapy Betters Crohn's Disease Results
Massive study of medical claims data points to initiating refined biologic therapies early in the .....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)