About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Promising Drug Therapies for Fatal Lung Disease Discovered

by Sheela Philomena on May 20, 2014 at 9:36 AM
Font : A-A+

 Promising Drug Therapies for Fatal Lung Disease Discovered

Drug pirfenidone slows the loss of lung function and reduces the risk of death in patients with idiopathic pulmonary fibrosis, says study.

The findings of the ASCEND drug trial are published online by the New England Journal of Medicine and are being presented this week at the International Conference of the American Thoracic Society in San Diego. "What we discovered about the anti-inflammatory and anti-fibrotic properties of pirfenidone offers help and encouragement to so many patients suffering from this relentless disease that robs them of breath and life," said Noble.

Advertisement

Idiopathic pulmonary fibrosis causes the regions of the lungs where oxygen gets to the blood to thicken and scar, leaving patients with shortness of breath, a chronic cough and extreme fatigue. Most patients die within two to five years of diagnosis.

"Not only did pirfenidone prevent the loss of lung function and preserve the distance patients could walk, but during the study the risk of death was reduced by a remarkable 48 percent in those taking the drug when compared with those who received placebo," said Noble." The findings were so strong that an early access program has been initiated to provide patients with pirfenidone while the process of obtaining FDA approval is undertaken. Cedars-Sinai will be participating in this program under the direction of Dr. Jeremy Falk and the Advanced Lung Disease Program.
Advertisement

Noble also was a co-author of a second study testing the efficacy and safety of the multi-kinase inhibitor nintedanib on idiopathic pulmonary fibrosis patients. Nintedanib is also is being studied in lung cancer.

"In our research we found that nintedanib could also slow the loss of lung function in patients with idiopathic pulmonary fibrosis," said Noble. "It is a second dose of good news for our patients because nintedanib not only slowed the progression of the disease, but it tended to reduce acute exacerbations of the disease, while tending to preserve the quality of life of the study patients receiving the drug." Noble is a paid consultant of InterMune Inc. and Boehringer-Ingelheim for his work on the steering committees of the two clinical trials. Cedars--Sinai was not among the medical centers participating in this multicenter study of the drug's efficacy in treating idiopathic pulmonary fibrosis.

"These IPF drug therapy findings by Dr. Noble and his colleagues exemplify the dedication and hard work required to find treatments for a group of patients who have so few therapeutic options because there have been no drugs approved by the Food and Drug Administration specifically targeted for treating this fatal disease," said Shlomo Melmed, MD, senior vice president and dean at Cedars-Sinai and the Helene A. and Philip E. Hixon Chair in Investigative Medicine.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test your Knowledge on Heart Transplantation
Test Your Knowledge on Lung Transplantation
Baldness can be Cured and Prevented: let us see How!
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Signature Drug Toxicity Sarcoidosis / Besnier - Boeck disease Asbestosis Pneumoconiosis Silicosis Pneumonectomy 

Most Popular on Medindia

Hearing Loss Calculator Noscaphene (Noscapine) Calculate Ideal Weight for Infants Blood Pressure Calculator Drug Interaction Checker Diaphragmatic Hernia Selfie Addiction Calculator Turmeric Powder - Health Benefits, Uses & Side Effects Find a Doctor Sanatogen
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT ONLINE WITH A DOCTOR