About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Promising Candidates for New HIV Drugs Found

by VR Sreeraman on October 15, 2009 at 4:37 PM
Font : A-A+

 Promising Candidates for New HIV Drugs Found

Studying an HIV protein that plays a key role in AIDS progression has helped University of Pittsburgh School of Medicine researchers discover compounds that show promise as novel treatments for the disease.

Study author Thomas E. Smithgall explained that HIV drug discovery efforts have met with little success in finding compounds that interact with an important HIV virulence factor, called Nef, because it lacks biochemical activity that can be directly measured.

Advertisement

To get around that problem, Smithgall's team developed an assay to measure Nef function indirectly by coupling it to another protein, called Hck, which Nef activates in HIV-infected cells.

Because Hck activity can be easily measured, the researchers were able to use it as a reporter for Nef activity in an automated high-throughput screening process.
Advertisement

The researchers screened a library of 10,000 chemical compounds against the coupled proteins to see which ones influenced Nef-induced activation of Hck.

After further testing, they confirmed that three compounds inhibited the activity of the Nef-Hck complex and, more importantly, all of them also interfered with HIV replication.

The researchers found that one compound was so effective that it suppressed HIV replication to undetectable levels in cell culture experiments.

"So we now have a way to rapidly and efficiently screen for inhibitors of Nef signaling through Hck. But the surprise was that some of those inhibitors also showed strong antiviral activity in cell culture models," Smithgall said.

He said that there is evidence that people infected with HIV variants that have mutations in the Nef gene take substantially longer to develop disease symptoms or AIDS. In animal models, disrupting the production of Nef from the virus or its interaction with Hck also delays or prevents disease symptoms.

The study was published in the early, online version of ACS Chemical Biology.

Source: ANI
LIN
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Oral Health And AIDS Drug Toxicity AIDS/HIV AIDS/HIV - Epidemiology AIDS/HIV - Clinical Features AIDS/HIV - Health Education AIDS/HIV - Prevention And Transmission AIDS / HIV - Treatment AIDS/HIV- Lab Tests and Faqs Signature Drug Toxicity 

Recommended Reading
AIDS / HIV - Treatment
Encyclopedia section of medindia explains in brief about the treatment for AIDS/HIV...
Quiz on HIV / AIDS
Statistics tell us that the world HIV+ population has risen drastically from 8 million in 1990 to a ...
HIV Drug Development Should Focus on Immune Cells
HIV drug development should target immune cells called macrophages, a new study has suggested....
AIDS/HIV
"AIDS is an epidemic disease, a potentially preventable, deadly infection for which there is no cure...
AIDS/HIV - Clinical Features
Encyclopedia section of medindia gives general info about HIV Clinical Features...
AIDS/HIV - Epidemiology
AIDS or HIV is an epidemic disease, a potentially deadly infection that can be prevented with preca...
AIDS/HIV - Health Education
Encyclopedia section of medindia gives general info about AIDS information and health education....
AIDS/HIV - Prevention And Transmission
Encyclopedia section of medindia explains in brief about the prevention for AIDS/HIV...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Oral Health And AIDS
AIDS has taken on massive proportions in modern times. It is estimated that over 15 million people a...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use