Multiple Myeloma / Plasma Cell Myeloma–Symptoms-Treatment-Prognosis-Support Group
Multiple Myeloma caught public attention when model turned actress Lisa Ray, who worked in Deepa Mehta’s ‘Water’ , declared that she had the incurable Multiple Myeloma.
Multiple Myeloma caught public attention when model turned actress Lisa Ray, who worked in Deepa Mehta’s ‘Water’ , declared that she had the incurable Multiple Myeloma.
‘Mutations alter the in multiple myeloma patients and increases the risk of progression to the symptomatic disease.
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The next-generation sequencing project "will help to explain the biology of the disease and how it unfolds through time from asymptomatic stages to symptomatic ones," said Mark Bustoros, MD, a postdoctoral fellow in the lab of Irene Ghobrial, MD."This research also will help us to understand which patients with SMM are at a high risk of progression, and eventually how we can target early stages of the disease, so that we don’t wait to treat them until the cancer cells are spread everywhere in the body and cause major organ damage," said Bustoros, who presented results of the study at the 59th American Society of Hematology (ASH) Annual Meeting and Exposition in Atlanta.
The scientists, led by Ghobrial, sequenced 186 bone marrow biopsies from patients with SMM, some of whom progressed to multiple myeloma and some of whom did not. They then matched up the genomic data with standard analyses of risks of progression provided by current non-genetic clinical biomarkers.
"We found that mutations were more frequent in the high-risk group of patients with SMM," Bustoros said. "We also found that certain mutations that are known to be drivers for cancer progression were more enriched in that group."
Many of the mutations were among genes in the MAPK and NF-kB molecular pathways, while others were MYC gene aberrations that are known to be altered in multiple myeloma. Patients who harbored these mutations had greater risk of progression to the symptomatic disease.
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Added Benefit Of Elotuzumab in Multiple Myeloma Not Proven
An added benefit of the new combination therapy in comparison with the appropriate comparator therapy is not proven for treatment of multiple Myeloma.
An added benefit of the new combination therapy in comparison with the appropriate comparator therapy is not proven for treatment of multiple Myeloma.
The study showed that the fractions of tumor DNA in the blood were higher in the high-risk SMM patients than in the low-risk SMM patients. The scientists hope to eventually develop ways to apply cfDNA sequencing to monitoring patients with myeloma and especially its precursor conditions, Monoclonal Gammopathy of Undetermined Significance (MGUS) and SMM.
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CAR T Immunotherapy Shows Promise in Treating Multiple Myeloma
Chimeric Antigen Receptor (CAR) T cell therapy has shown some promising results in multiple myeloma treatment option in patients who have had a relapse or were resistant
Chimeric Antigen Receptor (CAR) T cell therapy has shown some promising results in multiple myeloma treatment option in patients who have had a relapse or were resistant
The researchers now are sequencing dozens of additional patient samples, many of them from cancer centers around the country and the globe, and are looking for samples that span different points in time along myeloma progression.
"After finishing the study, we will integrate genomic and clinical data and try to construct a model that can be applied in the clinic, to identify patients who are at high risk of progression, and potentially to offer them earlier treatment," Bustoros said.
Source-Eurekalert
