About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Progression of Parkinson's Disease may be Predicted by Genetic Factors

by Kathy Jones on December 20, 2011 at 9:12 PM
Font : A-A+

 Progression of Parkinson's Disease may be Predicted by Genetic Factors

A new study has found that the speed of clinical deterioration in patients with Parkinson's disease my be influenced by different varieties of a-synuclein gene and its interaction with the microtubule-associated protein tau (MAPT) H1 haplotype.

According to Yue Huang and her team from the University of New South Wales, Sydney, Australia, Parkinson's disease is marked by the abnormal accumulation of a-synuclein NACP-Rep1 and the early loss of dopamine neurons in the substantia nigra region of the brain.

Advertisement

A polymorphism in the promotor of NACP-Rep1 has been implicated as a risk factor for the disease.

"Our data are the first to show that polymorphisms of NACP and MAPT interact to influence the rate of progression of Parkinson's disease, a finding with clinical utility," Huang said.
Advertisement

"Our study shows that genotypes for NACP and MAPT can be used as a surrogate marker for the estimated rate of Parkinson's disease progression, with positive predictive values of 94-100 percent for certain genotypes," she said.

123 patients with Parkinson's disease underwent genetic testing to determine NACP-Rep 1 and MAPT H1 allele or genotype. The patient's disease severity was measured using the Unified Parkinson's Disease Rating Scale (UPDRS), and a measurement of disease progression was calculated based on detailed information about disease and symptom onset.

Three common variations, or alleles, of NACP-Rep1 were detected. Patients with one '0' NACP-Rep1 allele had significantly slower disease progression compared to two or no '0' carriers.

This may partially reflect the known protective influence of '0' allele on Parkinson's disease. There was a high variation in the estimated rate of disease progression for the '0' allele group due to an interactive effect with the MAPT genotype.

The results of the study showed that a low relative risk for rapid clinical progression in patients with one NACP-1 '0' allele, or those carrying MAPT non-H1H1 genotype with two NACP-Rep1 '0's. In contrast there was a high risk of a fast clinical progression in patients carrying MAPT H1H1 genotype with two or no NACP-Rep1 '0's.

"Based on current knowledge, it is perhaps not surprising that genetic variation predisposing to high a-synuclein expression gives rise to more rapid progression of PD," Huang said.

"However, our results suggest that low a-synuclein expression may also be as detrimental in people with high tau expression levels, calling into question the concept that reducing neuronal a-synuclein in all PD patients may be therapeutically advantageous," she added.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Goji Berries May Protect Against Age-Related Vision Loss
Tapping — A Proven Self-Applied Stress Intervention
Black Pepper as Preventive Measure Against Omicron
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Genetics and Stem Cells Nutritional Management of Parkinsons disease Christianson Syndrome 

Recommended Reading
Parkinsons Disease
Parkinson's disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Parkinson's Disease - Animation
Slide animation on Parkinson disease. It is a progressive movement disorder due to degeneration of ....
Parkinson's Disease - Surgical Treatment - Animation
Slide animation on surgery for Parkinson disease. Surgery is only indicated where drugs fail to ......
Christianson Syndrome
Christianson syndrome is a condition that occurs due to mutations (abnormal changes) in the gene SLC...
Nutritional Management of Parkinsons disease
Parkinson's disease is a brain disorder which leads to many other related effects. Nutrition plays a...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)