About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Progression of Huntington's Disease may be Stopped by New Stem Cell Therapy

by Kathy Jones on January 23, 2012 at 10:33 PM
Font : A-A+

 Progression of Huntington's Disease may be Stopped by New Stem Cell Therapy

Researchers have developed a new technique using stem cells to deliver therapy that specifically targets the genetic abnormality found in Huntington's disease.

Huntington's is a hereditary brain disorder that causes progressive uncontrolled movements, dementia and death. This new approach might block Huntington's from advancing.

Advertisement

Researchers think that the best chance to halt the disease's progression will be to reduce or eliminate the mutant huntingtin (htt) protein found in the neurons of those with the disease.

"For the first time, we have been able to successfully deliver inhibitory RNA sequences from stem cells directly into neurons, significantly decreasing the synthesis of the abnormal huntingtin protein," Jan A Nolta, principal investigator of the study and director of the UC Davis stem cell program and the UC Davis Institute for Regenerative Cures, was quoted as saying.
Advertisement

Huntington's disease can be managed with medications, but currently there are no treatments for the physical, mental and behavioral decline of its victims.

"Our team has made a breakthrough that gives families affected by this disease hope that genetic therapy may one day become a reality," Nolta said.

RNA interference (RNAi) technology has been shown to be highly effective at reducing htt protein levels and reversing disease symptoms in mouse models.

"Our challenge with RNA interference technology is to figure out how to deliver it into the human brain in a sustained, safe and effective manner," said Nolta.

"We're exploring how to use human stem cells to create RNAi production factories within the brain," she said.

The findings of this study are available in the article 'Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin' that has been published online in the journal Molecular and Cellular Neuroscience.

Source: ANI
Advertisement
Advertisement
Advertisement

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Progression of Huntington's Disease may be Stopped by New Stem Cell Therapy Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests