Previous research has shown that colic affects about one in five infants in the United States annually. It also accounts for numerous pediatric visits during the first several months after birth.
Research into probiotic use for reduction of colic symptoms was showing promise; however, the April 1, 2014 issue of the British Medical Journal (BMJ2014;348:g2107; Sung, Valerie) reported on a study, "Probiotics and Infant Colic," concluding that the use of the probiotic L reuteri for infant colic did not reduce crying or fussing in infants nor was it effective in improving infant sleep, functioning or quality of life. The results were no different for babies receiving breast milk or formula.
"The role of different intestinal microbes in producing or alleviating colic remains a subject of interest," says Joel Lavine, M.D., Ph.D., professor of pediatrics and chief of pediatric gastroenterology, hepatology and nutrition at Columbia University Medical Center. "Some studies have identified changes in the colonization that are associated with colic, although these changes have not been shown to be causative, and the specific kinds of bacteria potentially responsible have not been identified. Thus far, manipulation of gut colonization by probiotics remains an inexact science and conflicting evidence exists regarding the efficacy of probiotics in improving the problem."
"Manipulation of bacterial populations in the gut may reduce the amount of gas produced by virtue of reducing lactose malabsorption," adds Dr. Lavine. "This problem of lactose malabsorption can be easily resolved by providing lactase to infants who are lacking, by way of commercially available infant drops."