About Careers MedBlog Contact us

Preventing Development of Asthma With Psychedelic Drug

by Himabindu Venkatakrishnan on February 10, 2015 at 9:21 PM
Font : A-A+

 Preventing Development of Asthma With Psychedelic Drug

A psychedelic drug, (R)-DOI, may help prevent asthma development. Research led by Charles Nicholas has found that this drug prevents the development of allergic asthma in a mouse model.

Charles Nichols, PhD is the Associate Professor of Pharmacology and Experimental Therapeutics at the LSU Health New Orleans School of Medicine.


The effects are potent and effective at a concentration 50-100 times less than would influence behavior.

Dr. Nichols said that these drugs are known only for their effects in the brain and they have demonstrated for the first time was that they are also effective in treating physiological diseases outside of the brain, a completely new and exciting role for this class of drug.

Not only was this a significant breakthrough in the field of study of serotonin and psychiatric drugs, but it was a breakthrough in the field of asthma as well and they have identified an entirely new anti-inflammatory mechanism for the treatment of asthma in the clinic that could someday be administered in an inhaler or a daily pill, he further added.

Previously, Dr. Nichols' lab found that activation of the serotonin receptor 5-HT2A with psychedelics produces powerful anti-inflammatory activity in tissues of the blood vessels and gut.

Building on that, the researchers identified a drug they believed would be effective against the inflammatory disease asthma.

They found that administration of (R)-DOI blocked pulmonary inflammation, mucus hyperproduction, and airways hyperresponsiveness and turned off certain key genes in the lung involved in immune response that together blocked the development of allergic asthma in their mouse model.

The research is published in the American Journal of Physiology - Lung Cellular and Molecular Physiology.

Source: ANI

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Preventing Development of Asthma With Psychedelic Drug Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests