Talking about food safety, Li said the issue is of utmost importance as it is directly related to people's health and life quality.
"The government should resolutely crack down on fake and substandard food products, and make those unscrupulous producers pay high prices," the premier said.
Li said the government will push forward scientific development, and deal with environment and food safety issues in a more transparent way.
Premier Li Keqiang has promised to tackle pollution and food safety problems with "iron fist and firm resolution."
"We will upgrade China's economic development model to enable people to enjoy clean air, safe drinking water and food," Li told a press conference on Sunday shortly after the conclusion of the annual legislative session.
Li said he felt "upset" about the smog that recently shrouded Beijing and large parts of the country's eastern areas.
"To tackle the problems, we need iron fist, firm resolution and tough measures," said the 57-year-old premier while meeting the press for the first time after assuming the post.
Li was endorsed as the Chinese premier Friday at the first session of the 12th National People's Congress, the country's top legislature.