Women who experience miscarriage and do not go on to have kids are at higher risk of developing heart disease compared to women who have only one or two children, reports a new study. The findings of the study are published in the Journal of Women's Health.
The study also found that women who have five or more children are at an increased risk of cardiovascular disease in later life.
Cardiovascular disease is the leading cause of death among women in every major developed country and most emerging economies.
During pregnancy, the mother's body experiences changes during pregnancy including weight gain and accumulation of abdominal fat, higher levels of cholesterol, increased insulin resistance, and changes in the structure of the heart. Although most changes that occur during pregnancy are temporary, these changes are known to be risk factors for cardiovascular disease in the general population.
Previous studies have attempted to assess the relationship between pregnancy and childbirth on the one hand and cardiovascular disease on the other. However, due to limitations in these studies - including not taking into account breastfeeding history and grouping together women who had never been pregnant with those who had been pregnant but experienced pregnancy loss - their results have been inconclusive and sometimes contradictory.
In this new study, a team of researchers in the US and the UK analyzed data from more than 8,500 White and African-American women, aged 45-64 years, in the US. This included health service data on cardiovascular disease over thirty years (1987-2016) and self-reported data on the number of pregnancies and births, and breastfeeding practices.
Within the study population, 138 women reported having experienced pregnancy loss and having no live-born children. 3,108 women had one or two live-born children, 3,126 had 3-4 liveborn children, and 1,694 had five or more live born children.
The researchers found that women who experienced pregnancy loss and did not have any live born children were at 64% greater risk of both coronary heart disease and 46% greater risk of heart failure compared to women with one or two children. Women with five or more births had a 38% higher risk of having a serious heart attack, regardless of how long they breastfed for.
The team says that there may be several possible reasons for the link between cardiovascular risk and multiple births. Repeated pregnancies could result in long-lasting changes within the body including weight gain, especially around the waist, and increased levels of cholesterol in the blood. Also, the number of children a woman has also encompassed other factors including child-rearing, age at menopause and health conditions. Therefore, the researchers say it is unclear whether the increased risk of heart failure, coronary heart disease, and heart attacks reflect the direct impact of repeated pregnancies, or the stressors associated with rearing multiple children, or both.
The increased risk of coronary heart disease and heart failure found in women with prior pregnancies, but no live-born children may reflect the increased risk previously identified after a history of miscarriage. Several mechanisms have been proposed to underlie the relationship between miscarriage and coronary heart disease, including immune disorders, chronic disease and dysfunction of the endothelium (cells that line the interior of blood vessels).
"Conditions such as heart disease and stroke together are the leading cause of death in women in the developed world, and it is essential that we understand why this is the case," says Dr Clare Oliver-Williams, a Junior Research Fellow at Homerton College who works at from the Department of Public Health and Primary Care at the University of Cambridge. "Our work suggests that there is a relation between cardiovascular disease risk and both pregnancy loss and having a large number of births.
"This study isn't designed to stress and worry women, especially those who have experienced the distress of pregnancy loss. Instead, we want to empower women with knowledge that will help them to reduce their risk.
"Most women know by the age of 40 how many children and pregnancy losses they have had, which is years before most heart attacks and strokes occur. This provides a window of opportunity to make lifestyle changes, such as exercise and diet that can help reduce the risk of cardiovascular disease."