Pregnant mothers aged 40 and over may have an increased risk for preterm birth, regardless of confounding factors.
Maternal age at pregnancy has been increasing worldwide and so has the risk of preterm birth. However, the association between maternal age and preterm birth remains a topic of ongoing research.
Fuchs and colleagues sought to investigate the impact of maternal age on preterm birth in a large cohort. The researchers analyzed the previously-collected data from the QUARISMA randomized controlled trial, which had taken place in 32 hospitals in Quebec, Canada, from 2008 to 2011.
Even after adjusting for confounding factors, the researchers found that advanced maternal age (40 or over) was associated with preterm birth. Meanwhile, a maternal age of 30-34 years was associated with the lowest risk of prematurity.