About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Preeclampsia Linked to Gene That Controls Immune System

by Kathy Jones on February 15, 2011 at 10:08 PM
Font : A-A+

 Preeclampsia Linked to Gene That Controls Immune System

The placentas of women who suffer preeclampsia during pregnancy have an overabundance of a gene associated with the regulation of the body's immune system, scientists have revealed.

The discovery by researchers at North Carolina State University may lead to improved screening and prenatal care for these patients and their babies.

Advertisement

Preeclampsia, a disorder is usually marked by a rapid rise in blood pressure that can lead to stroke, seizures or organ failures in the mother. Researchers have recently begun looking at preeclampsia as an autoimmune disorder, in which the mother's body treats the placenta like an invader, but they weren't sure of the genetic mechanisms involved.

Dr. Jorge Piedrahita, professor of genomics, along with colleagues from NC State and the Duke University School of Medicine, examined the genetic makeup of placentas from women with preeclampsia and compared the results to those from normal pregnancies.
Advertisement

"When we looked at the preeclampsic placentas, we found that several genes associated with a particular autoimmune pathway were 'upregulated' - basically, that there were more of them in placentas of preeclampsic women than in normal placentas," Piedrahita said.

"More specifically, we found the upregulation of a particular enzyme involved in sialic acid modification called SIAE. Sialic acid coats every cell in our body, making it possible for our immune system to distinguish 'self' from 'not-self.' If this process is disrupted, the body can end up attacking itself."

"Now we know that disregulation of SIAE helps start the cascade. We've been able to fill in the blanks, and hopefully pregnant women and their babies will benefit as a result, Piedrahita added.

The study has been published in the journal Placenta.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Myasthenia Gravis Swollen Ankles during Pregnancy HELLP Syndrome 

Most Popular on Medindia

Sanatogen Drug Interaction Checker Accident and Trauma Care The Essence of Yoga Color Blindness Calculator Blood Pressure Calculator How to Reduce School Bag Weight - Simple Tips Daily Calorie Requirements Pregnancy Confirmation Calculator Turmeric Powder - Health Benefits, Uses & Side Effects
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Preeclampsia Linked to Gene That Controls Immune System Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests