Powerful Antioxidant Can Reduce the Risk of Second Heart Attack, Stroke

Powerful antioxidant discovered lowers the risk of second heart attack or stroke which may help pave the way for new therapy. The findings of the study are published in the Journal of the American College of Cardiology.

Doctors have long known that in the months after a heart attack or stroke, patients are more likely to have another attack or stroke. A new study explains what happens inside blood vessels to increase risk - and suggests a new way to treat it.

What is a Heart Attack | How to Prevent Heart Attacks - Myocardial Infarction Smoking
Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoid heart attack are listed.

‘Cells and platelets stick inside arteries and increase the risk of second heart attack. Apocynin, a potent antioxidant can decrease the plaque buildup in half and lowers this risk. ’

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Heart attacks in mice caused inflammatory cells and platelets to more easily stick to the inner lining of arteries throughout the body and particularly where there was already plaque, according to the paper.

As a result, these sticky cells and platelets caused plaque to become unstable and contribute to blood clots that led to another heart attack or stroke.

But the study found treating mice that had experienced a heart attack or stroke with the powerful antioxidant apocynin cut plaque buildup in half and lowered inflammation to pre-attack levels.

Heart Attack - Overview
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the leading cause of death in the United States. Other names for heart attack include acute myocardial infarction, coronary thrombosis, and coronary occlusion.

"Knowing that newer forms of antioxidants such as apocynin can lower the risk of a second heart attack or stroke gives us a new treatment to explore and could one day help reduce heart attacks and strokes," said the paper's corresponding author, Jonathan R. Lindner, M.D., a professor of cardiovascular medicine at the OHSU School of Medicine.

Lindner penned the research paper with colleagues from OHSU, Scripps Research Institute and Bloodworks NW.

Tips to Prevent Heart Attacks
Heart Attack occurs when the flow of oxygenated blood to heart muscles is hindered or stopped due to built-up of plaques in coronary arteries. Heart Attack is the No.1 killer among Indians.

The researchers discovered the sticky cells and platelets by using unique forms of ultrasound imaging they developed to view molecules on the lining of blood vessels.

This research could help explain why the recent Canakinumab Anti-inflammatory Thrombosis Outcomes Study, also known as the CANTOS clinical trial, found an anti-inflammatory drug already approved to treat juvenile arthritis also reduced the risk of a second heart attack in trial participants by 15 percent.

Salt Consumption of Less Than 5 Grams a Day Does Not Increase Risk of Heart Attack or Stroke
Moderate consumption of salt (sodium) less than 5 grams daily may not increase risk of heart attacks or stroke according to a recent international study.

Lindner and his colleagues are further studying how the relative stickiness of remote arteries affects the risks of additional heart attacks and strokes and are also evaluating new therapies beyond antioxidants.

Source-Eurekalert