A new study published in the journal Particle & Particle Systems Characterization reveals that Swedish researchers have developed tiny particles that can allow effective delivery of cancer drugs to tumor cells. The researchers also revealed a method through which these particles can be made trackable on MR scanners.
The team, which consisted of scientists from Karolinska Institutet (KI) and the Royal Institute of Technology (KTH) in Stockholm, and from Chalmers University of Technology in Gothenburg, developed so-called 'theranostic nanoparticles' by combining therapy and diagnostics in one and the same nano material.
"For this study, we produced theranostic nanoparticles able to make pinpoint deliveries of drug payloads to breast cancer cells," says Professor Eva Malmström of the School of Chemical Science and Engineering at KTH. "They are also detectable in an MR scanner and can therefore be used diagnostically. The building blocks that we use are biodegradable and show no signs of toxicity."
The researchers filled the nanoparticles with the chemotherapeutic doxorubicin, which is used to treat cancer of the bladder, lungs, ovaries, and breast. They showed through experiments on cultivated cells that the particles, while harmless in themselves, are effective at killing cancer cells when loaded with the drug.
The next step is to develop the system to target brain tumours, pancreatic cancer and drug-resistant breast cancer tumours, which are currently difficult to treat effectively with chemotherapy.
"Adding targeting groups to the surface or by changing the size of or adding ionic groups to our nanoparticles will make it possible to increase the selective uptake of these particles in tumours," says Dr Andreas Nyström, Associate Professor in nanomedicine at the Swedish Medical Nanoscience Center, part of Karolinska Institutet's Department of Neuroscience.
It is hoped that one day this research will lead to tailored chemotherapy treatments that specifically seek out tumour cells. In that the drug, which is toxic to the body, can be delivered more precisely to the tumour, the treatment can be made much more effective with greatly reduced side-effects.