Over-expression of SLC6A14 protein in pancreatic tumors taken from patients and in cancerous pancreatic
cell lines compared with normal pancreatic tissue or normal pancreatic
SLC6A14 transports amino acids into cells to help with cellular metabolism.
"Finally, a novel strategy to treat pancreatic cancer: starve it to death!" said Dr. Yangzom Bhutia, senior author of the British Journal of Pharmacology study. "Pancreatic cancer recruits the transporter SLC6A14 to satisfy its increasing demands for amino acids; our studies show that if we block this transporter with a drug, we can effectively starve this cancer to death."
‘A blocker of SLC6A14, called α-methyltryptophan, induced amino acid starvation in pancreatic cancer cells and reduced the growth and proliferation of these cells, both in laboratory dishes and in mice.