Potential New Therapy Discovered for Opioid Tolerant Patients

by Bidita Debnath on February 17, 2015 at 11:26 PM

 Potential New Therapy Discovered for Opioid Tolerant Patients

Opioids are a widely used treatment for pain. Patients who take them on a regular basis can become tolerant, requiring a higher dose for continued pain relief.

In a study published in Anesthesiology, the official medical journal of the American Society of Anesthesiologists® (ASA®), researchers identified a compound that appears to play a role in the development of opioid tolerance. It may be possible to lessen the development of opioid tolerance if that compound is neutralized or blocked in patients taking opioids chronically for severe pain.


"Opioid tolerance is a growing problem among chronic pain patients and cancer patients in particular," said Chih-Peng Lin, M.D., assistant professor, Department of Anesthesiology, National Taiwan University College of Medicine. "We found that CXCL1, a protein produced by spinal cord tissue, contributes to opioid tolerance. By neutralizing CXCL1 in patients, we might help solve the problem of opioid tolerance."

While there has been extensive research on animals and opioid tolerance, this was the first study to examine both human patients and rats. The researchers compared patients with cancer-related pain controlled by strong opioids such as morphine with age-matched control subjects without cancer who were not taking opioids. They found that in both cancer patients and rats, subjects regularly given opioids and deemed opioid tolerant had an increased concentration of CXCL1 compared to those not regularly administered opioids. The rats were given additional CXCL1 in the space surrounding the spinal cord, which increased the rate of onset and severity of tolerance, providing further evidence that the protein contributes to tolerance. In a second phase of the study, the rats were administered a CXCL1 neutralizing or blocking agent that at least partially maintained the effectiveness of the opioid.

"Opioids are a mainstay of treatment for severe pain, especially cancer pain," said Dr. Lin. "By suppressing opioid tolerance, we can help patients achieve prolonged pain relief without the side effects of increased opioid dosages."

The study authors acknowledged that further research must be done to determine whether blocking CXCL1 will serve as a safe and effective way to eliminate tolerance of certain opioids in patients.

Source: Newswise

News A-Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cannabis Drug Abuse Reiki and Pranic Healing Drug Detox 

Recommended Reading
After Fivefold Increase Over a Decade, Prescriptions for Opioids are Stabilizing
Official data indicates that death rates from opioids have been soaring in the U.S. since the ......
Prescriptions for Benzodiazepines Rising and Risky When Combined With Opioids
Prescriptions for benzodiazepines are rising in primary care, and their frequent combined use with ....
Opioids and Their Relation to Chronic Pain
Though the dangers of hydrocodone, oxycodone and other opioids are well known, there is still a lot ...
High-dose Opioids Improves Mental and Physiologic Function
New research shows that half of patients on high-dose, long-term opioid therapy had hormonal ......
Cannabis has a long history of medicinal, recreational, and industrial use and comes from a bushy pl...
Drug Abuse
The use of Drugs for reasons other than its prescribed recommendation, is known as Drug abuse or sub...
Drug Detox
Drug detoxification (or drug detox) is a process that helps drug addicts to give up drugs with less ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use