A new study published in the journal Science Translational Medicine reveals that researchers at T2 Biosystems in Lexington, Massachusetts, have developed a new portable device to detect a fatal fungal bloodstream infection.
The researchers said that long detection time needed for Candida, a sepsis-causing fungus, results in approximately 40 percent mortality rate. The new device is based on T2 magnetic resonance (T2MR) and makes use of blood-compatible polymerase chain reaction to amplify Candida DNA from human whole blood.
This DNA then binds with nanoparticles that have been coated with a complementary DNA probe and yields nanoparticle clusters, which then change the sample's T2MR signal. The researchers added that the device can detect the presence of one colony-forming unit of five Candida species within three hours.