About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Popular Therapy Opted for Treating Prostate Cancer may Augment Spread of Disease

by VR Sreeraman on October 1, 2007 at 5:14 PM
Font : A-A+

Popular Therapy Opted for Treating Prostate Cancer may Augment Spread of Disease

Johns Hopkins researchers say that a popular prostate cancer treatment called androgen deprivation therapy may encourage prostate cancer cells to produce a protein that makes them more likely to spread throughout the body.

David Berman, an assistant professor of pathology, urology and oncology at The Johns Hopkins University School of Medicine, says that his team identified the unsuspected potential problem with the treatments that suppress testosterone, when they discovered that the gene that codes for the protein called nestin was active in lab-grown human prostate cancer cells.

Advertisement

With a view to determining whether prostate cancer cells in people also produce nestin, the researchers looked for it in cells taken from men who had surgery to remove locally confined cancers of their prostates, but found none.

However, the nestin gene was found to be active in prostate cancer cells isolated from patients who had died of metastatic prostate cancer, wherein cancer cells spread out from the prostate tumour.
Advertisement

Berman pointed out that it was almost certain that patients who eventually died because their disease metastasised were had received the androgen deprivation therapy, which reduces testosterone in the body is generally given when prostate cancers become aggressive and likely to metastasize.

He said that upon removal of androgen from the chemical mixture in which the cells live, the production of nestin increased.

With knowledge at hand that the nestin gene has long been suggested to play some role in cell growth and development, the researchers used laboratory sabotage called RNA interference to decrease the genetic expression of the gene.

They found that the cells were not able to move around and through other cells nearly as well as cells with normal nestin levels.

When prostate cancer cells with hampered nestin expression were transplanted into mice, the researchers found that such cells were less likely than normal prostate cancer cells to migrate to other parts of the body.

Berman, however, pointed out that though nestin expression seemed pivotal for metastasis in these experiments, it did not seem to make a difference in tumour growth.

"What all this suggests is that nestin levels increased when prostate cancer cells are deprived of androgens and may encourage the cells to metastasize," he said.

Source: ANI
SRM
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Prostate Cancer Cancer and Homeopathy Trans-Urethral Resection of the Prostate Reiki and Pranic Healing Prostate Cancer Facts Cancer Facts Cancer Prostate Cancer: Treatment Options Prostate Specific Antigen [PSA] Nutrition All Men Need 

Recommended Reading
Prostate Cancer - Animation
Interactive section of Medindia gives details regarding Prostate Cancer...
Nutrition All Men Need
Everyone requires good nutrition, be it man, woman, child or elderly. However, nutrition that men ne...
Prostate Cancer
This cancer affects men over the age of 50 years and screening with rectal examination and PSA can h...
Prostate Cancer: Treatment Options
Treatment options of prostate cancer includes waiting, surgery, radiation, hormone therapy, chemothe...
Prostate Specific Antigen [PSA]
PSA blood test is specific to prostate gland but not necessarily a cancer specific test but is commo...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use