Placental Dysfunction Can Now Be Detected Early

A powerful non-invasive MRI technique helps detect early placental dysfunction in pregnancies caused due to congenital heart disease (CHD).

A non-invasive imaging technique helps provide an early warning of placental dysfunction in pregnancies complicated by fetal congenital heart disease (CHD), reveals a new study.

A Children's National Health System research team is thought to be the first to report non-invasive, whole placenta perfusion imaging in utero in a study published online in Scientific Reports.

Morning Sickness Ups Pregnancy Risks
Hyperemesis gravidarum (morning sickness) in the second trimester of pregnancy is more likely to cause placental dysfunction disorders, states study.

‘Using MRI technology, placental dysfunction caused due to congenital heart disease (CHD) can be detected as early as the second trimester of pregnancy.’

According to the National Heart, Lung and Blood Institute, congenital heart defects are the most common type of birth defect, affecting 8 in 1,000 newborns.

Early in pregnancy, the fetal heart follows a parallel developmental course as the placenta, which supplies the growing fetus with oxygen and nutrients while ferrying out waste products.

The study authors write that placental arteries are dynamic during pregnancy, remodeling themselves to accommodate increased blood flow as fetuses undergo explosive growth spurts in later stages of pregnancy.

Independent Regulation Necessary for Ensuring Children�s Online Safety Says British Watchdog
A British child safety group has said that the child protection taken by social networking sites such as Facebook and Twitter are not enough.

If this crucial remodeling does not occur, the placenta may not supply sufficient oxygen and nutrients to the fetus, leading to fetal growth restriction or preeclampsia.

The research team led by Catherine Limperopoulos, Ph.D., enrolled 48 pregnant women who underwent at least one fetal magnetic resonance imaging (MRI) session during their second or third trimester of pregnancy.

Cardiorespiratory Fitness Levels may determine the Risk of CHD
Cardiorespiratory fitness levels may prove to be an important factor in Coronary Heart Disease (CHD) risk determination

Thirty-one of the women were healthy volunteers whose mean gestational age was 30 weeks (range: 21 to 39 gestational weeks). Seventeen women were pregnant with fetuses diagnosed with CHD whose mean gestational age was 32 weeks (range: 22 to 38 gestational weeks).

The researchers used velocity-selective arterial spin labeling (VSASL), a powerful MRI technique that directly measures the rate of delivery of arterial blood to organs like the brain. ASL tracks water molecules within the blood as blood flows through arteries, eliminating the need to use a contrast agent.

Russia to Repeal 'Gay Propoganda' Law, Urges UN Watchdog
UN urges Russia to repeal its controversial legislation banning gay propaganda because it is giving rise to discrimination and violence against young homosexuals and their families.

The team was able to distinguish the placenta perfusion contributions by the fetus and the mother.

"In pregnancies complicated by fetal CHD, global placental perfusion significantly decreased and regional variation of placental perfusion significantly increased with advancing gestational age," says Zungho "Wesley" Zun, Ph.D., the study's lead author.

"Just like the human brain, heart and kidneys--organs that can commandeer heightened blood flow when needed--the placenta may employ an auto-regulatory mechanism to optimize perfusion," adds Limperopoulos, director of Children's Developing Brain Research Laboratory and the study's senior author.

"The early increased global placental profusion in pregnancies complicated by CHD may represent an attempt to correct for insufficient fetal blood flow."

The research team writes that the findings demonstrate that placental dysfunction due to CHD can be apparent as early as the second trimester of pregnancy using this imaging technology.

"The predictive value of VSASL imaging, which we continue to study, holds the promise of detecting dysfunction before placental abnormalities become irreversible," Limperopoulos says.

Source-Eurekalert