About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

PET Scan Reveals Coffee's Effect on Human Brain

by VR Sreeraman on November 4, 2012 at 1:42 PM
Font : A-A+

 PET Scan Reveals Coffee's Effect on Human Brain

With the help of molecular imaging with positron emission tomography (PET) researchers have unveiled the possible positive and negative effects of caffeine consumption on human brain.

According to the new study, PET imaging with F-18-8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (F-18-CPFPX) shows that repeated intake of caffeinated beverages throughout a day results in up to 50 percent occupancy of the brain's A1 adenosine receptors.

Advertisement

"The effects of caffeine to the human body are generally attributed to the cerebral adenosine receptors. In the human brain the A1 adenosine receptor is the most abundant," David Elmenhorst, lead author of the study, said.

"In vitro studies have shown that commonly consumed quantities of caffeine have led to a high A1 adenosine occupancy. Our study aimed to measure the A1 adenosine receptor occupancy with in vivo imaging," he said.
Advertisement

Fifteen male volunteers participated in the study. They abstained from caffeine intake for 36 hours and then underwent a PET scan with F-18-CPFPX. Caffeine was then introduced in short intravenous infusions, increasing in amount.

To estimate the occupancy of A1 adenosine receptors by caffeine, the distribution volume at the baseline period of the PET scan was compared with the distribution volume after caffeine administration.

Researchers determined that the concentration of the caffeine that displaces 50 percent of the binding of F-18-CPFPX to the A1 adenosine receptor was 13 mg/L, or approximately four to five cups of coffee.

An important finding of the study is that in most regular coffee drinkers about half of the A1 adenosine receptors may be occupied by caffeine. It is likely that this blockage of a substantial amount of cerebral A1 adenosine receptors will result in adaptive changes and lead to chronic alterations of receptor express and availability.

"There is substantial evidence that caffeine is protective against neurodegenerative diseases like Parkinson's or Alzheimer's disease," Elmenhorst said.

"Several investigations show that moderate coffee consumption of 3 to 5 cups per day at mid-life is linked to a reduced risk of dementia in late life".

"The present study provides evidence that typical caffeine doses result in a high A1 adenosine receptor occupancy and supports the view that the A1 adenosine receptor deserves broader attention in the context of neurodegenerative disorders," he said.

The study has been published in The Journal of Nuclear Medicine.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Top 10 Vitamin B12 Foods for Vegetarians - Slideshow
Targeted Screening Program Beneficial for Prostate Cancer Screening
Are Menopause Symptoms Troubling You?: Try these Options
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Radioisotope Scan Parkinsons Disease Surgical Treatment Brain Brain Facts Coffee Ataxia Seven Surprisingly Healthy Foods Positron Emission Tomography Scan Single Photon Emission Computerized Tomography 

Most Popular on Medindia

Color Blindness Calculator Pregnancy Confirmation Calculator Iron Intake Calculator Find a Doctor Noscaphene (Noscapine) Drug - Food Interactions Daily Calorie Requirements Vent Forte (Theophylline) Diaphragmatic Hernia Blood Donation - Recipients

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use