About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Personalized Medicine To Be Possible by Genetic Technology

by Ramya Rachamanti on June 14, 2019 at 7:46 PM
Font : A-A+

Personalized Medicine To Be Possible by Genetic Technology

Comprehensive genetic testing panel called OncoKids was developed by the scientists and clinicians at Children's Hospital Los Angeles. This could be used to detect genetic markers that respond to targeted therapies helping to connect patients with life-saving clinical trials and medications.

Personalized medicine is the practice of tailoring disease prevention, diagnosis, and treatment to patients as individuals. Many cancers, for example, are resistant to conventional therapies but respond to medications that target specific cancer-causing genetic mutations.

Advertisement


Personalized medicine has expanded its capabilities as technology has grown. Scientists are now using a technology called metagenomic next-generation sequencing, or mNGS, to rapidly test clinical samples. This powerful assay can quickly compare unknown genetic material from a patient sample against thousands of known pathogen genomes.

"Basically, we can determine the cause of the disease, whether it's a virus, bacteria, or something else," says Jeffrey Bender, MD, a physician specializing in infectious diseases at CHLA. "If it has genetic material, this test can identify the infection and provide information that allows us to select a treatment specific to fight it."
Advertisement

Now that science has the capability to sequence and compare genomes, it is becoming clear that genomic testing can, and should be, used to identify infectious pathogens. This is especially important in diseases that could stem from multiple potential causes. For example, meningitis and encephalitis are serious central nervous system conditions that often arise from infection. Proper and timely diagnoses of these infections are critical so that patients can receive treatments before complications develop.

But many types of pathogens - bacteria, viruses, fungi, and parasites - can cause meningitis and encephalitis, making targeted testing difficult. Though laboratories can test samples for a handful of possible culprits, there is a limit to the number of pathogens they can test for at one time. Negative results can delay treatments and leave doctors, patients, and families searching for answers.

Now, clinicians at CHLA and sites nationwide are showing that broader genetic testing can deliver answers that standard laboratory tests fail to provide. Instead of one particular target, mNGS testing quickly compares sample genetic material to thousands of targets. Dr. Bender and Jennifer Dien Bard, PhD, Director of the Clinical Microbiology and Virology Laboratory at CHLA, participated in a multi-center clinical trial to evaluate the clinical use of mNGS testing in pediatric patients with suspected meningitis or encephalitis.

Their study, highlighted in the New England Journal of Medicine showed that this 'agnostic' testing could lead to treatments for infections that were not identified using standard testing methods. More than 200 patients at 8 hospitals, including CHLA, were enrolled in this year-long study. Cerebrospinal fluid was sampled from patients who presented with meningitis- or encephalitis-like symptoms.

Samples were then analyzed using either standard laboratory testing or mNGS. Out of 58 total diagnoses, sequencing identified 13 infections - more than 20% - that were not detected in standard clinical testing.

Dr. Dien Bard and her colleagues in the Center for Personalized Medicine envision a future in which these agnostic, genomic assays are integrated into routine clinical care. "The trial showed just how sequencing technology can really have a positive clinical impact on patients. In just this study alone, thirteen infections were diagnosed solely because of this technology," she says. "That's thirteen additional families who got answers."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Black Water: Benefits and Uses
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
Drinking This Popular Beverage May Drop Dementia Risk
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Genetics and Stem Cells Christianson Syndrome Personalized Medicine 

Most Popular on Medindia

Drug Side Effects Calculator The Essence of Yoga Post-Nasal Drip How to Reduce School Bag Weight - Simple Tips Daily Calorie Requirements Color Blindness Calculator Calculate Ideal Weight for Infants Iron Intake Calculator Sinopril (2mg) (Lacidipine) Accident and Trauma Care

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use