Patients with Alzheimer's disease can be classified by biomarkers in blood serum coupled with clinical information, states a new research.
Identifying biomarkers in the blood has several advantages over other methods of classifying patients with Alzheimer's disease, including detecting biomarkers in the cerebrospinal fluid and neuroimaging.
Alzheimers Disease
Alzheimer''s disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others.
Advertisement
Blood can be collected at any clinic or in-home visit and most patients will agree to the process, whereas not all facilities can conduct lumbar punctures to obtain cerebrospinal fluid.
Sid E. O'Bryant of Texas Tech University Health Sciences Center and colleagues analysed proteins in the serum of 197 patients diagnosed with Alzheimer's disease and 203 controls without Alzheimer's disease.
![Clinical Trials]( "Clinical Trials")
Clinical trials are experiments that yield useful information to clinicians if a particular treatment is of any value to a patient.
The final biomarker risk score correctly identified 80 percent of the individuals with Alzheimer's disease and accurately excluded 91 percent of the individuals without Alzheimer's disease.
When other factors were also considered-age, sex, education and whether an individual had the APOE gene, which is associated with risk for Alzheimer's disease-the score correctly identified 94 percent of the individuals with Alzheimer's disease and accurately classified 84 percent of participants who did not have the disease.
"In addition to offering more accessible, rapid and cost- and time-effective methods for assessment, biomarkers also hold great potential for the identification of endophenotypes within Alzheimer's disease populations that are associated with particular disease mechanisms," the authors wrote.
The study appeared in Archives of Neurology, one of the JAMA/Archives journals.
Source: ANI
Clinical Trials
Clinical trials are experiments that yield useful information to clinicians if a particular treatment is of any value to a patient.
Advertisement
The final biomarker risk score correctly identified 80 percent of the individuals with Alzheimer's disease and accurately excluded 91 percent of the individuals without Alzheimer's disease.
When other factors were also considered-age, sex, education and whether an individual had the APOE gene, which is associated with risk for Alzheimer's disease-the score correctly identified 94 percent of the individuals with Alzheimer's disease and accurately classified 84 percent of participants who did not have the disease.
"In addition to offering more accessible, rapid and cost- and time-effective methods for assessment, biomarkers also hold great potential for the identification of endophenotypes within Alzheimer's disease populations that are associated with particular disease mechanisms," the authors wrote.
The study appeared in Archives of Neurology, one of the JAMA/Archives journals.
Source: ANI
Biomarkers That can Predict Chronological and Physiological Age Identified
In a first of its kind study, scientists at the Buck Institute for Age Research have uncovered biomarkers of aging, which can predict both chronological and physiological age.
Advertisement
 Biomarkers in Spinal-Fluid May Help Predict Alzheimer's AccuratelyAlzheimer's disease can be predicted with up to 100 percent accuracy several years before its onset using biomarkers found in spinal fluids, a study published Monday showed. | Advertisement
|
Advertisement
Recommended Readings
Latest Mental Health News
The type of microglia appears to be key important for fine-tuning anxiety and obsessive compulsive disorder behaviors.
The study sheds light on the genetic architecture of bipolar disorder and provides more insights into the contribution of mosaic variants in human diseases.
People who live in disadvantaged neighbourhoods along with depressive symptoms tend to undergo premature aging.
There is an urgent need for mental health care in injured children after firearm injuries.
Recently, a noteworthy transformation has occurred, with 81 percent of workplaces now placing increased emphasis on employee mental health.