About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Penn Medicine Study: Resistance To Drugs Shown By Sons of Cocaine-using Fathers

by Rukmani Krishna on November 16, 2013 at 11:53 PM
Font : A-A+

 Penn Medicine Study: Resistance To Drugs Shown By Sons of Cocaine-using Fathers

New findings from an animal study suggest that a father's cocaine use may make his sons less sensitive to the drug and thereby more likely to resist addictive behaviors. The study was presented by Penn Medicine researchers at Neuroscience 2013, the annual meeting of the Society for Neuroscience.

The study, led by Mathieu Wimmer, PhD, a post-doctoral researcher in the laboratory of R. Christopher Pierce, PhD, associate professor of Neuroscience in Psychiatry at the Perelman School of Medicine at the University of Pennsylvania, found that sons, but not females, of male rats on cocaine were not only less likely to want the drug, but also resistant to effects of it. This suggests cocaine causes epigenetic changes-that is alterations to DNA that do not involve changing the sequence-in sperm in which reprogrammed information is transmitted down to the next generation of men.

Advertisement

Last year, Dr. Pierce and colleagues found that cocaine abuse in a male rat rendered the next generation of animals resistant to the rewarding properties of the drug-those offspring were less likely to take cocaine. They found changes in the brain-derived neurotrophic factor (BDNF), which is a molecule known to be important for the rewarding efficacy of cocaine, but only by looking at molecular signaling pathways in progeny that had never experienced cocaine.

In the current study, the authors focused on the physiology of neurons before and after taking cocaine in the offspring of cocaine-experienced fathers, and found that they were less sensitive to the drug and less likely to succumb to addictive behaviors.
Advertisement

In short, not only are rat offspring of cocaine-abusing fathers less likely to take the drug on their own volition, they are less likely to become addicted to it if they are administered it.

In male rats whose fathers used cocaine, the neurons in the nucleus accumbens were less sensitive to cocaine. That is, repeated cocaine use in the sons of cocaine-experienced fathers did not cause remodeling of excitatory AMPA receptors, which is thought to be critical for the development of addiction and cocaine craving.

"This adds to the growing body of evidence that cocaine abuse in a father rat can affect how his sons may respond to the drug—and point to potential mechanisms that contribute to this phenomenon," said Wimmer. "Further research is needed to better understand how these behavior changes are passed down from one animal generation to the next, and eventually if the same holds true for humans."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Monkeypox Outbreak: What it is, How Does it Spread & the Prevention
Seasonal Allergy Medications
How to Choose the Best Eczema-Friendly Moisturizer for Children?
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Drugs Banned in India 

Most Popular on Medindia

Noscaphene (Noscapine) Loram (2 mg) (Lorazepam) Find a Hospital Hearing Loss Calculator Color Blindness Calculator Drug Side Effects Calculator Diaphragmatic Hernia Turmeric Powder - Health Benefits, Uses & Side Effects How to Reduce School Bag Weight - Simple Tips Sanatogen

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use