About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Pathogenic Protein Alteration can Help Treat Tuberculosis

by Rishika Gupta on October 14, 2017 at 12:27 PM
Font : A-A+

Pathogenic Protein Alteration can Help Treat Tuberculosis

By the use of a pioneering method, the research team from Instituto de Medicina Molecular (IMM) has discovered the defense mechanism of pathogenic protein and a way to bypass it found a new study published in Chem journal.

To design novel drugs it is essential to understand the molecular mechanisms that make up proteins of pathogenic bacteria.

Advertisement


The team, led by Gonçalo Bernardes, used an innovative methodology that allows protein alteration in their native state along with organic chemistry, biological computation, biophysics, and biochemistry techniques to modify proteins involved in infectious diseases.

Researchers were able to identify a novel molecular mechanism that works as a shield in a family of proteins that are present in pathogenic bacteria, named phosphates.
Advertisement

In particular, the team observed the presence of a structural water molecule in a specific area that protects the protein of being inactivated by oxidative processes.

These results may impact the fields of medical chemistry and molecular medicine because they reveal a novel defense mechanism used by these pathogenic proteins which may prove essential in the way we think about novel drug design, particularly to increase specificity, potency, and efficacy of future clinical tests.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Tuberculosis Tracheostomy Pleural Effusion Silicosis Magical Millets for Your Health Screening Tests for Tuberculosis Fever Cough Symptom Evaluation Diet and Nutrition Tips for Athletes Nutrition IQ 
Recommended Reading
Cough Symptom Evaluation
Cough is a symptom of a condition usually affecting the respiratory tract. It may be acute or chroni...
Diet and Nutrition Tips for Athletes
Athletes can be physically fit by consuming a well balanced nutritious diet, which keeps them mental...
Fever
Fever or Pyrexia is an elevation in normal body temperature. Causes of fever include infections, inj...
Magical Millets for Your Health
Millets are far more nutrient dense than wheat and rice. They are inexpensive and tasty too. Nutriti...
Pleural Effusion
Pleural effusion is the accumulation of fluid in the space between the two coverings (pleura) of the...
Screening Tests for Tuberculosis
Tuberculin skin test and Interferon – Release Assays are tests used to screen for tuberculosis....
Silicosis
Silicosis is a lung disease caused by inhalation of crystalline free silica dust. It is characterise...
Tuberculosis
Tuberculosis, caused by Mycobacterium tuberculosis, primarily affects the lung. It may spread to oth...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use