How paternal aging influences the behavior of offspring that inherit a genetic risk has been described by researchers.
Genetic Intersection of Neurodevelopmental Disorders and Co-Occuring Medical Conditions
Researchers have analyzed current gene-disease findings to understand why people with neurodevelopmental and mental illness often have physical disorders.
Researchers have analyzed current gene-disease findings to understand why people with neurodevelopmental and mental illness often have physical disorders.
‘Paternal aging influences the behavior of offspring that inherit a genetic risk. This could explain why there is a rapid rise in the ratio of children with neurodevelopmental disorders.’
In the experiments, in order to minimize the physical influence of
the father, the male mouse was isolated and in vitro fertilization was
used to impregnate the female. The researchers found that the offspring
of young fathers exhibited impaired vocal communication, while the
offspring of older fathers exhibited hyperlocomotion. The results are significant for both animal researchers and the public. For researchers working on animal models, it shows that the age of male mice can influence the behavior of the offspring, so this should be a consideration when they are used to mate.
For the public, the research shows that paternal aging may exacerbate genetic risks - this could explain why there is a rapid rise in the ratio of children with ASD or ADHD, due to men having children later in life.
New Genetic Pathway Behind Neurodevelopmental Disorders Discovered
Researchers have identified a novel genetic process that could one day provide a target for the treatment of neurodevelopmental disorders, such as intellectual disability and autism.
Researchers have identified a novel genetic process that could one day provide a target for the treatment of neurodevelopmental disorders, such as intellectual disability and autism.
1 in 10 Kids Born With Kidney Defects are Genetically Susceptible to Neurodevelopmental Disorders
Researchers at Columbia University Medical Center have found that nearly 10 percent of children who are born with kidney defects also have large alterations in their genetic makeup.
Researchers at Columbia University Medical Center have found that nearly 10 percent of children who are born with kidney defects also have large alterations in their genetic makeup.
Study of Neurodevelopmental Disorders Beyond Single Diagnosis
Analysis of neurodevelopmental disorder genes and their psychiatric phenotypes revealed a striking degree of overlap between seemingly unrelated disorders.
Analysis of neurodevelopmental disorder genes and their psychiatric phenotypes revealed a striking degree of overlap between seemingly unrelated disorders.
