About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Pancreatic Cancer may be Treated by Drug Combo

by Kathy Jones on June 17, 2010 at 11:22 PM
Font : A-A+

 Pancreatic Cancer may be Treated by Drug Combo

A new study says that cancer medication sorafenib, which is used for advanced liver and kidney cancer, appears to be effective against cancer stem cells in pancreatic cancer.

The findings of the study appear online in the journal Cancer Research.

Advertisement

The team led by Professor Dr. Ingrid Herr, Head of the Department of Molecular Oncosurgery, a group of the Department of Surgery at Heidelberg University Hospital, in cooperation with the German Cancer Research Center, tested sorafenib in mice and pancreatic cancer cells.

It inhibits resistant tumour stem cells and is also especially effective in combination with sulforaphane, an organic compound found in broccoli.
Advertisement

In their tests on cancer cells and mice, the researchers showed that sorafenib inhibited typical properties of cancer stem cells from pancreas tumours and greatly reduced tumour growth.

However, this effect lasted only for a short time and after four weeks, new colonies of cancer stem cells formed that no longer reacted to further treatment with sorafenib.

"This resistance is probably related to a certain metabolic pathway, the NF-kB pathway, that is activated by sorafenib," explained Vanessa Rausch, a young researcher at the department of Surgery at Heidelberg University Hospital and first author of the article.

There are naturally occurring substances that block precisely this undesired NF-KB pathway and thus make the dangerous cells vulnerable: vegetables from the cruciferous family such as broccoli and cauliflower possess a high content of sulforaphane, an anti-cancer compound.

The experiments show that sulforaphane prevents the activation of the NF-kB pathway by sorafenib.

The combination treatment reinforces the effect of sorafenib without causing additional side effects.

The invasive potential of cancer cells was prevented - metastasis was completely blocked in cell culture experiments.

"We assume that nutrition may be a suited approach to break therapy resistance of cancer stem cells and thus make tumour treatment more effective," Professor Herr said.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Pancreatic Cancer Drug Toxicity Cancer and Homeopathy Signature Drug Toxicity Cancer Facts Cancer Tattoos A Body Art Pancreatitis Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant 

Most Popular on Medindia

Color Blindness Calculator Turmeric Powder - Health Benefits, Uses & Side Effects Blood Pressure Calculator Noscaphene (Noscapine) Nutam (400mg) (Piracetam) Drug Side Effects Calculator Vent Forte (Theophylline) Find a Doctor Indian Medical Journals Find a Hospital
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Pancreatic Cancer may be Treated by Drug Combo Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests