In women, popular pain-reliving drugs like ibuprofen or acetaminophen lead to hearing loss, finds study published in American Journal of Epidemiology. There was no association between aspirin use and hearing loss, say researchers.
The researchers prospectively examined the relationship between frequency of aspirin, ibuprofen and acetaminophen use and risk of hearing loss among women in the Nurses' Health Study II.
Data from 62,261 women ages 31 to 48 years at baseline was studied. The women were followed for 14 years, from 1995 to 2009. Ten thousand and twelve women self-reported hearing loss.
Compared with women who used ibuprofen less than once per week, those who used ibuprofen 2 to 3 days per week had a 13 percent increased risk for hearing loss, while women who used the medication 4 to 5 days per week had a 21 percent increased risk. For those who used ibuprofen six or more days per week, the increased risk was 24 percent.
Compared with women who used acetaminophen less than once per week, women who used acetaminophen 2 to 3 days per week had an 11 percent increased risk for hearing loss, while women taking the medicine 4 to 5 days per week had a 21 percent increased risk.
"Possible mechanisms might be that NSAIDs may reduce blood flow to the cochlea—the hearing organ—and impair its function," said first study author Sharon G. Curhan, MD, BWH Channing Division of Network Medicine. "Acetaminophen may deplete factors that protect the cochlea from damage."
Curhan notes that although analgesics are widely available without a prescription, they are still medicines that carry potential side effects.
"If individuals find a need to take these types of medications regularly, they should consult with their health care professional to discuss the risks and benefits and to explore other possible alternatives," said Curhan.
Over 50 percent of American adults suffer from high-frequency hearing loss by the time they reach 60 years old. One-third of women in their 50s and nearly two-thirds in their 60s have experienced hearing loss.
According to the World Health Organization, adult-onset hearing loss is the sixth most common disease burden in high-income countries.