About My Health Careers Internship MedBlogs Contact us

Paediatric Brain Tumours may Be Destroyed by Drug-Coated Nanoparticles

by Rajashri on July 15, 2008 at 4:09 PM
Font : A-A+

 Paediatric Brain Tumours may Be Destroyed by Drug-Coated Nanoparticles

Cancer killing drugs may soon be delivered to pediatric brain tumors, according to scientists at Washington University in St. Louis.

Lead researcher on the project, Dr. Karen L. Wooley, says that her team has developed polymeric nanoparticles that can trap a drug called doxorubicin, commonly used in chemotherapy, and slowly release it over an extended time period.


She says that the release rate of the drug can be tailored, and its solubility improved by fine-tuning the polymer composition.

Writing about this research in Chemical Communications, the researchers revealed that the new approach allowed them to load more doxorubicin into the cores of the nanoparticles, compared with similar constructs.

"Typically, a polymeric micelle has three to four percent (drug) loading per nanoparticle mass. In our case, we achieved 18 to 19 percent for our nanoparticles," said Dr. Andreas Nystrom, a post-doctoral associate, who worked on the project.

The nanoparticles carrying the doxorubicin, however, were not as effective at killing cancer cells as the neat drug, admitted the researchers.

The reasons they suggested were that no targeting groups were included in the initial nanoparticles, and the entire drug payload of the nanoparticle was not released.

According to the researchers, the drug-filled nanoparticles can be made effective for treating brain tumours by decorating them with signatures that will direct them to the tumours, and away from healthy cells, a process known as tissue specific targeting.

Once attached to the tumour, the nanoparticles can release their deadly contents, killing the cancer cells and leaving the healthy cells unharmed.

"Everything depends on getting the nanoparticle to the tissue (tumor) of choice," said Nystrom.

Wooley agrees: "We have been studying these nanoparticles for some time now as a platform technology, achieving high radiolabeling efficiencies and demonstrating variable bio-distributions through a collaboration with the laboratory of Professor Mike Welch, in the Department of Radiology. Now, we are poised to take advantage of the progress made to develop the particles for diagnosis and treatment of several diseases."

She adds: "In this latest work, the nanoparticles were designed with thermally tunable core properties to serve as a host system that retains drug molecules at room temperature and then releases the cargo at physiological temperature, with a controlled drug release profile.

The results are highly promising and are allowing us to move forward to a fully functional, tumor-targeted drug delivery device. The key to making this happen is the interdisciplinary team of investigators, each of whom brings a different chemical, biological or medical expertise."

Source: ANI

News A-Z
News Category
What's New on Medindia
Health Benefits of Sea Buckthorn
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Parkinsons Disease Surgical Treatment Brain Tumor Markers For Cancer Diagnosis and Prognosis Brain Facts Ataxia Pediatric Pyloric Stenosis Language Areas in The Brain Ways to Improve your Intelligence Quotient (IQ) 

Recommended Reading
Brain Tumor
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors ....
Human Skin Protein Attacked By Mobile Phone Radiations
Mobile phone users have been frequently cautioned about the possible ill effects its radiations ......
Genetic Mapping Could Help for Better Diagnosis, Treatment of Common Tumors
Researches have developed a genetic mapping tool which could allow for better diagnosis and ......
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Pediatric Pyloric Stenosis
Pyloric stenosis in a child is narrowing of the pylorus due to which the milk cannot pass into the s...
Tumor Markers For Cancer Diagnosis and Prognosis
An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive...
Ways to Improve your Intelligence Quotient (IQ)
Intelligence quotient (IQ) is a psychological measure of human intelligence. Regular physical and me...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use