This is the second time Princess Cruises' 3,0080-passenger "Crown Princess" has had an outbreak of Norovirus this year. More than 150 passengers caught the virus during a cruise in April.
The ship has docked near Los Angeles and the cruise line is conducting a cleaning of the vessel and consulting with the CDC on sanitation procedures, the report said.
A CDC health officer will board the ship to evaluate the outbreak and response Sunday.
The vacation cruise ship is finishing a 28-day journey from Los Angeles to Hawaii and Tahiti.
Princess Cruises told AFP the ship will undergo an "extensive deep cleaning" before it makes its next trip.
The Crown Princess is scheduled to go to Mexico on November 29.
Source: AFP