About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Oxycodone Use Shifts After the Introduction of Tamper-resistant Versions

by Colleen Fleiss on March 27, 2018 at 2:23 AM
Font : A-A+

Oxycodone Use Shifts After the Introduction of Tamper-resistant Versions

In Australia, after the introduction of tamper-resistant oxycodone, dispensing rates for higher-strength formulations decreased for people younger than 65 years, revealed study published in CMAJ. The effect had no change in older adults, added scientists.

Canada, the United States and Australia are the highest per capita consumers of opioids worldwide. Opioid use has increased 15-fold in Australia over 20 years (1992 to 2012), making it the country with the second highest per capita consumption of oxycodone. In 2014, the country introduced tamper-resistant controlled-release oxycodone.

Advertisement


The study looked at whether reformulation changed use of controlled-release oxycodone and opioid-related harms in a sample cohort of 36 528 adults who had at least one filled prescription for oxycodone during the study period (July 2012 to November 2016). After reformulation, dispensing of oxycodone in both 10-30 mg and 40-80 mg strengths gradually decreased for people under age 65 years, for total decreases of 11% and 31.5%, respectively. People younger than 65 years, especially those younger than 45 years, were more likely to switch to morphine after reformulation, and there was an increase in participants of all ages switching to oxycodone/naloxone.

"The observed decline in dispensing of higher-strength oxycodone controlled-release in participants less than 65 years of age may be due to an increase in switching to other strong opioids, chiefly morphine, rather than an increase in ending use," writes Dr. Andrea Schaffer, University of New South Wales, Sydney, Australia, with coauthors. "This is of concern because it suggests that people may be seeking out opioids without tamper-resistant properties." The authors note that as the study was observational, the results do not indicate causation between reformulation and changes in behaviour, but rather an association.
Advertisement

Despite reductions in dispensing of stronger oxycodone, poisonings from injected oxycodone did not decrease, as measured by calls to the New South Wales Poison Information Centre, which receives about 50% of all poisoning calls yearly in Australia. "We did not find an increase in ending use of strong opioids in parallel with an increase in switching to other non-tamper-resistant strong opioids," write the authors.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
Toothache
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
Drug Detox
Drug detoxification (or drug detox) is a process that helps drug addicts to give up drugs with less ...
Drug Abuse
The use of Drugs for reasons other than its prescribed recommendation, is known as Drug abuse or ......
Drug Abuse Screening Test
Drug Abuse Screening Test (DAST) is a screening test to find out if you need professional help with ...
Oxycodone Hydrochloride
This medication is a narcotic pain reliever, prescribed for moderate to severe ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use