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Ovarian Cancer Growth Blocked by Motor Regulatory Protein

by Kathy Jones on April 28, 2011 at 8:32 PM
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 Ovarian Cancer Growth Blocked by Motor Regulatory Protein

A new mice study has revealed that over-expression of the protein km23-1 was responsible for causing the death of ovarian cancer cells.

Pulipati et al conducted this animal study after assessing the results of a previous study, which showed that a subunit of the motor protein dynein called km23-1 was defective in ovarian cancer patients. This protein is the one that transports checkpoint proteins along the microtubules during mitosis.

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In this particular study, researchers induced over-expression of km23-1 in human ovarian cancer cells transplanted in mice. The researchers reported that the size of the tumors in mice with this over-expressed protein was significantly reduced compared to mice, which did not have over-expression of this protein.

The study is explained in detail in the latest issue of the International Journal of Cancer.




Source: Medindia
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