About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Our Body Clock Affects Severity of Autoimmune Disease

by Bidita Debnath on December 12, 2017 at 11:19 PM
Font : A-A+

Our Body Clock Affects Severity of Autoimmune Disease

Circadian rhythms or 24-hour rhythms are generated by the body clock, allowing us to anticipate and respond to the 24-hour cycle of our planet.

Understanding the effect of the interplay between 24-hour day-night cycles and the immune system may help inform drug-targeting strategies to alleviate autoimmune disease.

Advertisement


Insights into how the body clock and time of day influence immune responses are revealed in a study published in leading international journal Nature Communications. Maintaining a good body clock is generally believed to lead to good health for humans, and disrupting the circadian rhythm (for example, working night shifts) has been associated with immune diseases such as multiple sclerosis; however, the underlying molecular links have been unclear.

In the new study, Professor Kingston Mills and Dr Caroline Sutton of Trinity College Dublin, and Dr Annie Curtis of RCSI (Royal College of Surgeons Ireland), and colleagues show that immune responses and regulation of autoimmunity are affected by the time of the day when the immune response is activated.
Advertisement

Using mice as a model organism, they show that a master circadian gene, BMAL1, is responsible for sensing and acting on time-of-the-day cues to suppress inflammation. Loss of BMAL1, or induction of autoimmunity at midday instead of midnight, causes more severe experimental autoimmune encephalomyelitis, which is essentially an analogue of multiple sclerosis in mice.

Professor of Experimental Immunology at Trinity, Kingston Mills, said: "In the year that the Nobel Prize in Medicine was awarded for discoveries on the molecular mechanisms controlling the circadian rhythm, our exciting findings suggest that our immune system is programmed to respond better to infection and insults encountered at different times in the 24-hour clock. This has significant implications for the treatment of immune-mediated diseases and suggests there may be important differences in time of day response to drugs used to treat autoimmune diseases such as multiple sclerosis."

Although further investigations are needed to understand how to precisely modulate circadian rhythm or time-of-the-day cues for beneficial immunity, the findings in this article serve well to remind us the importance of 'keeping the time' when dealing with the immune system.

Research Lecturer in the Department of Molecular and Cellular Therapeutics at RCSI, Dr Annie Curtis, said: "Our study also shows how disruption of our body clocks, which is quite common now given our 24/7 lifestyle and erratic eating and sleeping patterns, may have an impact on autoimmune conditions."

"We are really beginning to uncover exactly how important our body clocks are for health and wellbeing."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Breast Cancer Awareness Month 2021 - It's time to RISE
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Circadian Rhythm Sleep Disorders Chemotherapy Chemotherapy Drugs Multiple Sclerosis Myasthenia Gravis Healthy Living Multiple Sclerosis Treatment and Modify Vitiligo Autoimmune Disorders Granulomatosis with Polyangiitis (GPA) 

Recommended Reading
Can Autoimmune Disease After a Viral Infection be Prevented?
Autoimmune diseases like rheumatoid arthritis, lupus erythematosus or multiple sclerosis after an .....
Risk of Heart Disease Higher in Those With Autoimmune Diseases
Crohn's and ulcerative colitis, rheumatoid arthritis and other inflammatory diseases increase the .....
A Test to Detect an Autoimmune Disease
The immune system tends to wrongly identify its 'enemy' in autoimmune diseases,and produces ......
High Tech Microscope Used to Find Clues of an Autoimmune Disease
Scientists were trying to visualize antibodies that cause neuromyelitis optica (NMO), a rare ......
Autoimmune Disorders
Autoimmune disorders occur when the immune system fails to recognize the body as ‘self’ and attacks ...
Chemotherapy
‘Chemo’ means medicine or ‘drug’; ‘therapy’ means ‘treatment’. Chemotherapy refers to the use of cy...
Chemotherapy Drugs
Chemotherapy drugs perform like ‘magic bullets’ to destroy cancer cells in the body....
Circadian Rhythm Sleep Disorders
Circadian rhythm (also known as sleep/wake cycle or the body clock) is a biological process that fol...
Granulomatosis with Polyangiitis (GPA)
Granulomatosis with Polyangiitis (GPA) is a type of vasculitis that usually affects the upper airway...
Multiple Sclerosis
Multiple sclerosis can be a severely disabling autoimmune disease that affects the myelin or insulat...
Multiple Sclerosis Treatment and Modify
Multiple sclerosis is treated with drugs that modify the course of the disease, suppress immunity an...
Myasthenia Gravis
Myasthenia gravis is the commonest disorder of neuromuscular transmission. Autoimmune myasthenia gra...
Vitiligo
Vitiligo is a skin disease characterized by patches of unpigmented skin. Vitiligo is usually slowly ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use