Ototoxic Drug-induced Hearing Loss in Mice Can Be Prevented By Sound Preconditioning

Irreversible hearing loss is caused by death of sensory hair cells in the ear. Several classes of drugs, including aminoglycoside antibiotics and chemotherapy drugs are known to kill hair cells; however, in many cases the benefit of using the drug outweighs the potential for hearing loss.

Previous research has shown that a class of proteins induced in response to cell stress, the heat shock proteins (HSPs), can protect against sensory hair cell death in response to ototoxic drugs. Despite understanding how HSPs protect the hair cells of the inner ear, there are no current therapies to induce expression of or deliver HSP directly to the inner ear. In this issue of the Journal of Clinical Investigation, Lisa Cunningham and colleagues at the National Institutes of Health developed a sound preconditioning protocol in mice that did not damage hearing, but induced HSP expression in the ear. They found that sound conditioning prior to treatment with ototoxic drugs, protected mice from drug-induced hearing loss.

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