About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Osteoporosis Drug Raloxifene to Be Trialled in Schizophrenia Treatment

by Gopalan on September 8, 2008 at 9:40 AM
Font : A-A+

 Osteoporosis Drug Raloxifene to Be Trialled in Schizophrenia Treatment

Australian researchers are to trial raloxifene, now used in osteoporosis and cancer, for schizophrenia treatment.

The three-year clinical drug trial follows the discovery that in schizophrenics a brain receptor that normally stimulates growth in adolescence is disabled.

Advertisement

Professor Cyndi Shannon Weickert, who holds Australia's first Chair of Schizophrenia Research, said, "We now know that this brain receptor doesn't work in the normal way for people with schizophrenia.

"With this drug trial, we can begin to stimulate it and try and get the neurodevelopmental program back on track.

For some patients we could see improvements in language and memory," says Professor Shannon Weickert.
Advertisement

Her position is a joint initiative of UNSW, the Prince of Wales Medical Research Institute and the Schizophrenia Research Institute.

Her team's findings are published in Human Molecular Genetics.

Researchers are recruiting 80 male and female patients with schizophrenia who will receive the new therapy in addition to their ongoing medication. The aim of the new trial is to learn how raloxifene can influence thought processing in schizophrenia and determine whether it could be used as a novel therapeutic treatment for cognitive problems in patients.

Raloxifene is a hormonal modulator that stimulates the oestrogen receptor in the brain. It does not simulate the oestrogen receptor in other parts of the body.

Raloxifene (brand name: Evista) is a drug that helps prevent and treat osteoporosis in postmenopausal women. Bone loss is common in postmenopausal women. Raloxifene works like the hormone estrogen to slow this bone loss and can even help increase normal bone growth.

Estrogen can cause side effects like vaginal bleeding and breast tenderness. It can also increase the risk of breast or uterine cancer. Raloxifene doesn't have these same side effects. In addition, raloxifene also lowers total and low-density lipoprotein (LDL) cholesterol (also known as "bad" cholesterol) but won't raise high-density lipoprotein (HDL) cholesterol (also known as "good" cholesterol). Raloxifene is being tested to see if it lowers the risk of heart disease and breast cancer.

Source: Medindia
GPL/M
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Cervical Cancer Awareness Month 2022
Ultra-Low-Fat Diet
Goji Berries May Protect Against Age-Related Vision Loss
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Fracture Rickets Osteoporosis Schizophrenia Lifestyle And Osteoporosis Kyphosis Signature Drug Toxicity Colle’s Fracture Fracture Neck of Femur 

Recommended Reading
Schizophrenia
Schizophrenia is a mental disorder characterized by symptoms of thought, behavior and social ......
Colle’s Fracture
Colles fracture or broken wrist is a wrist fracture, which occurs within an inch of the wrist joint....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Fracture
A fracture is a condition where the continuity of the bone is lost. Majority of bone fractures occur...
Kyphosis
Kyphosis is a spinal disorder, which is derived from Greek word – 'kyphos' which means bowed or ben...
Lifestyle And Osteoporosis
Encyclopedia section of medindia briefly explains about Lifestyle and Osteoporosis...
Osteoporosis
Osteoporosis is a bone disease that leads to an increased risk of fractures. The bone mass is reduce...
Rickets
Encyclopedia section of medindia explains in brief about Rickets...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)