Pancreatic Cancer - All About the Disease, its Diagnosis and Management
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
‘Cold Spring Harbor Laboratory (CSHL) is at the forefront of using organoid technology to study and treat cancer.’
Tweet it Now
Getting quick results is important because pancreatic cancer patients usually do best if they undergo chemotherapy to shrink their tumor prior to surgery, explains Lyudmyla Demyan, a lead author of the study. Demyan is a research fellow in Tuveson’s lab and a surgeon at Northwell Health. If the first round of chemotherapy is not effective, the patient may be switched to a different regimen. But, Demyan says, “you’ve already lost that critical window of opportunity to treat cancer. You’re kind of losing grip on it—it’s spreading very quickly.”
Pancreatic Cancer Treatment
The new study is part of an effort to expand organoids’ role in improving clinical care. “Organoids enable us to recreate and recapitulate each patient’s tumor,” explains Amber Habowski, a postdoctoral fellow in the Tuveson lab and another lead author of the study. “We then have a model system for each individual patient that we can test drugs on. The idea behind personalized medicine is that if the organoid responds really well, we can maybe predict the patient would also.”Cold Spring Harbor Laboratory (CSHL) runs one of the largest cancer organoid facilities in the country, working on a wide range of cancers. Currently, it leads a clinical trial called Pancreatic Adenocarcinoma Signature Stratification for Treatment (PASS-01). It is evaluating personalized therapy based on how individual patients’ organoids respond to different chemotherapy treatments. The new pilot test may further optimize personalized chemotherapy treatments. Demyan hopes she will be able to use the test one day soon to help her patients.
Source-Eurekalert
Quiz on Pancreatic Cancer
Pancreatic cancer is often diagnosed at a late stage and can be fatal. Test your knowledge on pancreatic cancer by taking this quiz.
Pancreatic cancer is often diagnosed at a late stage and can be fatal. Test your knowledge on pancreatic cancer by taking this quiz.
mRNA Vaccine Trial for Pancreatic Cancer
An mRNA-based vaccine for pancreatic cancer has shown promise for remission. 50% of patients remained cancer-free 18 months after having their tumors removed.
An mRNA-based vaccine for pancreatic cancer has shown promise for remission. 50% of patients remained cancer-free 18 months after having their tumors removed.
Is Exercise a Lifesaver for Pancreatic Cancer Treatment?
Insight into how the human immune system is designed to attack foreign invaders like bacteria and can also recognize cancer cells as abnormal in the pancreas.
Insight into how the human immune system is designed to attack foreign invaders like bacteria and can also recognize cancer cells as abnormal in the pancreas.
