A recent study points out that menopausal women who are on hormone replacement therapy are at an increased risk for gallbladder disease.

It was seen that nearly 64.8% of them were on HRT at least once. Analysts found about 2819 incident of cholecystectomies and 2608 of those patients were on HRT.
Moreover, those were on oral HRT were at a much higher risk for gallbladder disease and consequent removal of gallbladder than those who took oral HRT.
These findings fall in line with previous studies reporting the increased risk of gallbladder disease with HRT in menopausal women.
Source-Medindia