Oral bacteria may trigger the risk of pancreatic cancer, reports a new study. The findings of the study are published in the journal Gut.
The presence of oral bacteria in cystic pancreatic tumors is associated with the severity of the tumor, a new study suggests.
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‘Oral bacteria may increase the risk of pancreatic cancer. However, rinsing the mouth with an antibacterial agent and ensuring good oral hygiene can help reduce the risk of transferring oral bacteria to the pancreas.’
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According to the researcher, the results can help to reappraise the role of bacteria in the development of pancreatic cysts. If further studies show that the bacteria actually affects the pathological process, it could lead to new therapeutic strategies using antibacterial agents.
"We were surprised to find oral bacteria in the pancreas, but it wasn't totally unexpected. The bacteria we identified has already been shown in an earlier, smaller study to be higher in the saliva of patients with pancreatic cancer," said co-author Margaret Sallberg Chen from the Karolinska Institutet in Sweden.
![Pancreatic Cancer]( "Pancreatic Cancer")
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
Not all pancreatic tumors are cancerous. For instance, there are so-called cystic pancreatic tumors (pancreatic cysts), many of which are benign. A few can, however, become cancerous, the researcher said.
"We find most bacteria at the stage where the cysts are starting to show signs of cancer," Chen said.
"What we hope is that this can be used as a biomarker for the early identification of the cancerous cysts that need to be surgically removed to cure cancer..." she added.
For the study, the team examined the presence of bacterial DNA in fluid from pancreatic cysts in 105 patients and compared the type and severity of the tumors.
The results showed that the fluid from the cysts with high-grade dysplasia and cancer contained much more bacterial DNA than that from benign cysts.
To identify the bacteria, the researchers sequenced the DNA of 35 of the samples that had high amounts of bacterial DNA.
They found large variations in the bacterial composition between different individuals, but also a greater presence of certain oral bacteria in fluid and tissue from cysts with high-grade dysplasia and cancer.
Source: IANS
Pancreatic Cancer
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
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Not all pancreatic tumors are cancerous. For instance, there are so-called cystic pancreatic tumors (pancreatic cysts), many of which are benign. A few can, however, become cancerous, the researcher said.
"We find most bacteria at the stage where the cysts are starting to show signs of cancer," Chen said.
"What we hope is that this can be used as a biomarker for the early identification of the cancerous cysts that need to be surgically removed to cure cancer..." she added.
For the study, the team examined the presence of bacterial DNA in fluid from pancreatic cysts in 105 patients and compared the type and severity of the tumors.
The results showed that the fluid from the cysts with high-grade dysplasia and cancer contained much more bacterial DNA than that from benign cysts.
To identify the bacteria, the researchers sequenced the DNA of 35 of the samples that had high amounts of bacterial DNA.
They found large variations in the bacterial composition between different individuals, but also a greater presence of certain oral bacteria in fluid and tissue from cysts with high-grade dysplasia and cancer.
Source: IANS
New Blood Test Can Quickly Detect Pancreatic Cancer
A new blood test has been developed by researchers that can detect pancreatic cancer in less than an hour, finds study.
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Tongue Microbiome Could Help Early Detection of Pancreatic CancerTongue coat microbiome is altered in pancreatic cancer patients. The change in the degree of colonization of bacteria could help in developing rapid diagnostic methods for early detection of pancreatic cancer. | Advertisement
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